Self-selected women with polycystic ovary syndrome are reproductively and metabolically abnormal and undertreated

Richard Legro, Margrit Urbanek, Allen Kunselman, Benjamin E. Leiby, Andrea Dunaif

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objective: To determine whether self-selected women with polycystic ovary syndrome (PCOS) are abnormal compared with a control population. Design: Case-control. Setting: Support group meeting organized and initiated by patients. Patient(s): Forty-five self-selected women with PCOS and 80 control women. Intervention(s): Self-selected women with PCOS at a peer support conference completed a questionnaire, had a brief physical, and gave a fasting blood sample. Main Outcome Measure(s): Historical, biometric, and assay results. Result(s): Sixty percent of the women attending the conference participated in the study. Most had been diagnosed with PCOS on the basis of ovarian morphology (35%). They were more likely to be nulliparous and have a history of oligomenorrhea (96%). They were hyperandrogenemic (significantly elevated testosterone and DHEAS levels) compared with control women. Self-selected women with PCOS displayed multiple metabolic abnormalities compared with control women, including elevations in blood pressure, waist-hip ratio, fasting insulin, fasting total cholesterol, and fasting low-density lipoprotein cholesterol levels, as well as a significant decrease in fasting glucose-insulin ratio and high-density lipoprotein cholesterol levels. Conclusion(s): Self-selected women with PCOS have reproductive and metabolic abnormalities. The majority of these women received inadequate treatment despite having risk factors for endometrial cancer, diabetes, and/or heart disease. Our study also suggests that women attending or participating in a PCOS support group are willing and likely to participate in clinical studies.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalFertility and sterility
Volume78
Issue number1
DOIs
StatePublished - Jul 15 2002

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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