Sensitivities and specificities of diagnostic tests and infection prevalence of Schistosoma haematobium estimated from data on adults in villages northwest of Accra, Ghana

Artemis Koukounari, Joanne P. Webster, Christi A. Donnelly, Bethany Cara Bray, Jean Naples, Kwabena Bosompem, Clive Shiff

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Substantial uncertainties surround the sensitivities and specificities of diagnostic techniques for urinary schistosomiasis. We used latent class (LC) modeling to address this problem. In this study, 220 adults in three villages northwest of Accra, Ghana were examined using five Schistosoma haematobium diagnostic measures: microscopic examination of urine for detection of S. haematobium eggs, dipsticks for detection of hematuria, tests for circulating antigens, antibody tests, and ultrasound scans of the urinary system. Testing of the LC model indicated non-invariance of the performance of the diagnostic tests across different age groups, and measurement invariance held for males and females and for the three villages. We therefore recommend the use of LC models for comparison between and the identification of the most accurate schistosomiasis diagnostic tests. Furthermore, microscopy and hematuria dipsticks were indicated through these models as the most appropriate techniques for detection of S. haematobium infection.

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume80
Issue number3
StatePublished - Mar 2009

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Schistosoma haematobium
Ghana
Routine Diagnostic Tests
Hematuria
Sensitivity and Specificity
Infection
Schistosomiasis haematobia
Schistosomiasis
Eggs
Uncertainty
Microscopy
Age Groups
Urine
Antigens
Antibodies

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Koukounari, Artemis ; Webster, Joanne P. ; Donnelly, Christi A. ; Bray, Bethany Cara ; Naples, Jean ; Bosompem, Kwabena ; Shiff, Clive. / Sensitivities and specificities of diagnostic tests and infection prevalence of Schistosoma haematobium estimated from data on adults in villages northwest of Accra, Ghana. In: American Journal of Tropical Medicine and Hygiene. 2009 ; Vol. 80, No. 3. pp. 435-441.
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Sensitivities and specificities of diagnostic tests and infection prevalence of Schistosoma haematobium estimated from data on adults in villages northwest of Accra, Ghana. / Koukounari, Artemis; Webster, Joanne P.; Donnelly, Christi A.; Bray, Bethany Cara; Naples, Jean; Bosompem, Kwabena; Shiff, Clive.

In: American Journal of Tropical Medicine and Hygiene, Vol. 80, No. 3, 03.2009, p. 435-441.

Research output: Contribution to journalArticle

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