Sensitivity of 341 non-fermentative gram-negative bacteria to seven beta-lactam antibiotics

P. C. Appelbaum, J. Tamim, J. Stavitz, Robert Aber, G. A. Pankuch

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Susceptibility of 341 isolates of non-fermentative gram-negative bacteria to carbenicillin, piperacillin, cefoperazone, moxalactam, cefotaxime, ceftizoxime, and N-formimidoyl thienamycin was determined by the agar dilution and disc diffusion methods. Piperacillin was the most active agent against Pseudomonas aeruginosa, thienamycin the most active against Pseudomonas fluorescens and Pseudomonas putida, and moxalactam the most active against Pseudomonas maltophilia. Piperacillin and thienamycin were the most active agents against the other Pseudomonas species studied. Thienamycin proved to have excellent activity against Acinetobacter calcoaceticus - 90 % of strains were inhibited by ≤ 1 μg/ml. The two most active drugs against Alcaligenes species were piperacillin and thienamycin, both of which inhibited 90 % of isolates at a concentration of 2 μg/ ml. All drugs were active against Moraxella species. The broad sensitivity spectrum of piperacillin, thienamycin, and the third-generation cephalosporins against non-fermentative gram-negative bacteria indicates their potential use in infections caused by these organisms.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalEuropean Journal of Clinical Microbiology
Volume1
Issue number3
DOIs
StatePublished - Jun 1 1982

Fingerprint

beta-Lactams
Piperacillin
Gram-Negative Bacteria
Anti-Bacterial Agents
Moxalactam
Moraxella
Ceftizoxime
Acinetobacter calcoaceticus
Stenotrophomonas maltophilia
Alcaligenes
Carbenicillin
Cefoperazone
Pseudomonas fluorescens
Pseudomonas putida
Cefotaxime
Cephalosporins
Pseudomonas
Pharmaceutical Preparations
Pseudomonas aeruginosa
Agar

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)

Cite this

Appelbaum, P. C. ; Tamim, J. ; Stavitz, J. ; Aber, Robert ; Pankuch, G. A. / Sensitivity of 341 non-fermentative gram-negative bacteria to seven beta-lactam antibiotics. In: European Journal of Clinical Microbiology. 1982 ; Vol. 1, No. 3. pp. 159-165.
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Sensitivity of 341 non-fermentative gram-negative bacteria to seven beta-lactam antibiotics. / Appelbaum, P. C.; Tamim, J.; Stavitz, J.; Aber, Robert; Pankuch, G. A.

In: European Journal of Clinical Microbiology, Vol. 1, No. 3, 01.06.1982, p. 159-165.

Research output: Contribution to journalArticle

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