Separable bilayer microfiltration device for label-free enrichment of viable circulating tumor cells

Sijie Hao, Merisa Nisic, Hongzhang He, Yu Chong Tai, Si Yang Zheng

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Analysis of rare circulating tumor cells enriched from metastatic cancer patients yields critical information on disease progression, therapy response, and the mechanism of cancer metastasis. Here we describe in detail a label-free enrichment process of circulating tumor cells based on its unique physical properties (size and deformability). Viable circulating tumor cells can be successfully enriched and analyzed, or easily released for further characterization due to the novel separable two-layer design.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages81-91
Number of pages11
DOIs
StatePublished - Jan 1 2017

Publication series

NameMethods in Molecular Biology
Volume1634
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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  • Cite this

    Hao, S., Nisic, M., He, H., Tai, Y. C., & Zheng, S. Y. (2017). Separable bilayer microfiltration device for label-free enrichment of viable circulating tumor cells. In Methods in Molecular Biology (pp. 81-91). (Methods in Molecular Biology; Vol. 1634). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7144-2_6