Separation of Serotonin from Catechols by Capillary Zone Electrophoresis with Electrochemical Detection

Ross A. Wallingford, Andrew G. Ewing

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

Capillary zone electrophoresis with electrochemical detection is demonstrated with columns having only 9-μm inner diameter. Amperometrlc detection limits of 0.7 amol are reported for serotonin. The difficult problem of resolving serotonin and dopamine—two neurotransmitters of interest having similar electrophoretic mobilities—is addressed by chemical means to Improve selectivity. These include buffer modification with 2-propanol and a system employing borate complexation of the catechol in combination with sodium dodecyl sulfate micelles.

Original languageEnglish (US)
Pages (from-to)98-100
Number of pages3
JournalAnalytical Chemistry
Volume61
Issue number2
DOIs
StatePublished - Jan 1989

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Fingerprint

Dive into the research topics of 'Separation of Serotonin from Catechols by Capillary Zone Electrophoresis with Electrochemical Detection'. Together they form a unique fingerprint.

Cite this