Sequence variants and the risk of head and neck cancer

Pooled analysis in the INHANCE consortium

Shu Chun Chuang, Antonio Agudo, Wolfgang Ahrens, Devasena Anantharaman, Simone Benhamou, Stefania Boccia, Chu Chen, David I. Conway, Eleonora Fabianova, Richard B. Hayes, Claire M. Healy, Ivana Holcatova, Kristina Kjaerheim, Pagona Lagiou, Philip Lazarus, Tatiana V. Macfarlane, Manoj B. Mahimkar, Dana Mates, Keitaro Matsuo, Franco Merletti & 22 others Andres Metspalu, Hal Morgenstern, Joshua Muscat, Gabriella Cadoni, Andrew F. Olshan, Mark Purdue, Heribert Ramroth, Peter Rudnai, Stephen M. Schwartz, Lorenzo Simonato, Elaine M. Smith, Erich M. Sturgis, Neonilia Szeszenia-Dabrowska, Renato Talamini, Peter Thomson, Qingyi Wei, David Zaridze, Zuo Feng Zhang, Ariana Znaor, Paul Brennan, Paolo Boffetta, Mia Hashibe

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

Original languageEnglish (US)
Article number00013
JournalFrontiers in Oncology
Volume1
Issue numberJUL
DOIs
StatePublished - Dec 1 2011

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Head and Neck Neoplasms
Epidemiology
Odds Ratio
Confidence Intervals
Homozygote
Single Nucleotide Polymorphism
Genotype
Central Asia
Heterozygote
DNA Repair
Case-Control Studies
Epidemiologic Studies
Cell Cycle
Logistic Models

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Chuang, S. C., Agudo, A., Ahrens, W., Anantharaman, D., Benhamou, S., Boccia, S., ... Hashibe, M. (2011). Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium. Frontiers in Oncology, 1(JUL), [00013]. https://doi.org/10.3389/fonc.2011.00013
Chuang, Shu Chun ; Agudo, Antonio ; Ahrens, Wolfgang ; Anantharaman, Devasena ; Benhamou, Simone ; Boccia, Stefania ; Chen, Chu ; Conway, David I. ; Fabianova, Eleonora ; Hayes, Richard B. ; Healy, Claire M. ; Holcatova, Ivana ; Kjaerheim, Kristina ; Lagiou, Pagona ; Lazarus, Philip ; Macfarlane, Tatiana V. ; Mahimkar, Manoj B. ; Mates, Dana ; Matsuo, Keitaro ; Merletti, Franco ; Metspalu, Andres ; Morgenstern, Hal ; Muscat, Joshua ; Cadoni, Gabriella ; Olshan, Andrew F. ; Purdue, Mark ; Ramroth, Heribert ; Rudnai, Peter ; Schwartz, Stephen M. ; Simonato, Lorenzo ; Smith, Elaine M. ; Sturgis, Erich M. ; Szeszenia-Dabrowska, Neonilia ; Talamini, Renato ; Thomson, Peter ; Wei, Qingyi ; Zaridze, David ; Zhang, Zuo Feng ; Znaor, Ariana ; Brennan, Paul ; Boffetta, Paolo ; Hashibe, Mia. / Sequence variants and the risk of head and neck cancer : Pooled analysis in the INHANCE consortium. In: Frontiers in Oncology. 2011 ; Vol. 1, No. JUL.
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abstract = "Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95{\%} confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95{\%} CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95{\%} CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95{\%} CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95{\%} CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95{\%} CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20{\%}). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.",
author = "Chuang, {Shu Chun} and Antonio Agudo and Wolfgang Ahrens and Devasena Anantharaman and Simone Benhamou and Stefania Boccia and Chu Chen and Conway, {David I.} and Eleonora Fabianova and Hayes, {Richard B.} and Healy, {Claire M.} and Ivana Holcatova and Kristina Kjaerheim and Pagona Lagiou and Philip Lazarus and Macfarlane, {Tatiana V.} and Mahimkar, {Manoj B.} and Dana Mates and Keitaro Matsuo and Franco Merletti and Andres Metspalu and Hal Morgenstern and Joshua Muscat and Gabriella Cadoni and Olshan, {Andrew F.} and Mark Purdue and Heribert Ramroth and Peter Rudnai and Schwartz, {Stephen M.} and Lorenzo Simonato and Smith, {Elaine M.} and Sturgis, {Erich M.} and Neonilia Szeszenia-Dabrowska and Renato Talamini and Peter Thomson and Qingyi Wei and David Zaridze and Zhang, {Zuo Feng} and Ariana Znaor and Paul Brennan and Paolo Boffetta and Mia Hashibe",
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Chuang, SC, Agudo, A, Ahrens, W, Anantharaman, D, Benhamou, S, Boccia, S, Chen, C, Conway, DI, Fabianova, E, Hayes, RB, Healy, CM, Holcatova, I, Kjaerheim, K, Lagiou, P, Lazarus, P, Macfarlane, TV, Mahimkar, MB, Mates, D, Matsuo, K, Merletti, F, Metspalu, A, Morgenstern, H, Muscat, J, Cadoni, G, Olshan, AF, Purdue, M, Ramroth, H, Rudnai, P, Schwartz, SM, Simonato, L, Smith, EM, Sturgis, EM, Szeszenia-Dabrowska, N, Talamini, R, Thomson, P, Wei, Q, Zaridze, D, Zhang, ZF, Znaor, A, Brennan, P, Boffetta, P & Hashibe, M 2011, 'Sequence variants and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium', Frontiers in Oncology, vol. 1, no. JUL, 00013. https://doi.org/10.3389/fonc.2011.00013

Sequence variants and the risk of head and neck cancer : Pooled analysis in the INHANCE consortium. / Chuang, Shu Chun; Agudo, Antonio; Ahrens, Wolfgang; Anantharaman, Devasena; Benhamou, Simone; Boccia, Stefania; Chen, Chu; Conway, David I.; Fabianova, Eleonora; Hayes, Richard B.; Healy, Claire M.; Holcatova, Ivana; Kjaerheim, Kristina; Lagiou, Pagona; Lazarus, Philip; Macfarlane, Tatiana V.; Mahimkar, Manoj B.; Mates, Dana; Matsuo, Keitaro; Merletti, Franco; Metspalu, Andres; Morgenstern, Hal; Muscat, Joshua; Cadoni, Gabriella; Olshan, Andrew F.; Purdue, Mark; Ramroth, Heribert; Rudnai, Peter; Schwartz, Stephen M.; Simonato, Lorenzo; Smith, Elaine M.; Sturgis, Erich M.; Szeszenia-Dabrowska, Neonilia; Talamini, Renato; Thomson, Peter; Wei, Qingyi; Zaridze, David; Zhang, Zuo Feng; Znaor, Ariana; Brennan, Paul; Boffetta, Paolo; Hashibe, Mia.

In: Frontiers in Oncology, Vol. 1, No. JUL, 00013, 01.12.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sequence variants and the risk of head and neck cancer

T2 - Pooled analysis in the INHANCE consortium

AU - Chuang, Shu Chun

AU - Agudo, Antonio

AU - Ahrens, Wolfgang

AU - Anantharaman, Devasena

AU - Benhamou, Simone

AU - Boccia, Stefania

AU - Chen, Chu

AU - Conway, David I.

AU - Fabianova, Eleonora

AU - Hayes, Richard B.

AU - Healy, Claire M.

AU - Holcatova, Ivana

AU - Kjaerheim, Kristina

AU - Lagiou, Pagona

AU - Lazarus, Philip

AU - Macfarlane, Tatiana V.

AU - Mahimkar, Manoj B.

AU - Mates, Dana

AU - Matsuo, Keitaro

AU - Merletti, Franco

AU - Metspalu, Andres

AU - Morgenstern, Hal

AU - Muscat, Joshua

AU - Cadoni, Gabriella

AU - Olshan, Andrew F.

AU - Purdue, Mark

AU - Ramroth, Heribert

AU - Rudnai, Peter

AU - Schwartz, Stephen M.

AU - Simonato, Lorenzo

AU - Smith, Elaine M.

AU - Sturgis, Erich M.

AU - Szeszenia-Dabrowska, Neonilia

AU - Talamini, Renato

AU - Thomson, Peter

AU - Wei, Qingyi

AU - Zaridze, David

AU - Zhang, Zuo Feng

AU - Znaor, Ariana

AU - Brennan, Paul

AU - Boffetta, Paolo

AU - Hashibe, Mia

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

AB - Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in the metabolism, cell cycle, and DNA repair pathways and the risk of head and neck cancer. We analyzed individual-level pooled data from 14 European, North American, Central American, and Asia case-control studies (5,915 head and neck cancer cases and 10,644 controls) participating in the INHANCE consortium. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for SNP effects, adjusting for age, sex, race, and country. We observed an association between head and neck cancer risk and MGMT Leu84Phe heterozygotes (OR = 0.79, 95% CI = 0.68-0.93), XRCC1 Arg194Trp homozygotes Arg/Arg (OR = 2.3, 95% CI = 1.1-4.7), ADH1B Arg48His homozygotes Arg/Arg (OR = 2.7, 95% CI = 1.9-4.0), ADH1C Ile350Val homozygotes Ile/Ile (OR = 1.2, 95% CI = 1.1-1.4), and the GSTM1 null genotype (OR = 1.1, 95% CI = 1.0-1.2). Among these results, MGMT Leu84Phe, ADH1B Arg48His, ADH1C Ile350Arg, and the GSTM1 null genotype had fairly low false positive report probabilities (<20%). We observed associations between ADH1B Arg48His, ADH1C Ile350Arg, and GSTM1 null genotype and head and neck cancer risk. No functional study currently supports the observed association for MGMT Leu84Phe, and the association with XRCC1 Arg194Trp may be a chance finding.

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DO - 10.3389/fonc.2011.00013

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