Sequential longitudinal evaluation of cardiac growth and ventricular diastolic filling in fetuses of well controlled diabetic mothers

Howard Weber, J. J. Botti, B. G. Baylen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Hypertrophic cardiomyopathy and abnormal ventricular diastolic filling in the infant of the diabetic mother is related to poor maternal glycemic control. Evaluation of fetuses of well controlled diabetic mothers has not been examined. Eleven fetuses of nondiabetic mothers (normals) and 9 fetuses of well controlled insulin-dependent diabetic mothers (FODMs) under-went serial evaluation of cardiac growth and ventricular diastolic filling using M-mode and Doppler echocardiography at 20-26 weeks' (period 1), 27-33 weeks' (period 2), 34-40 weeks' (period 3), and 48-72 hours after birth (period 4). Indices of right and left ventricular diastolic filling included time velocity integral ratios (E/A and %E/E + A). Cardiac growth and birth weight in the two groups were similar consistent with "good" glycemic control. This conclusion was supported by similar maternal glycosylated hemoglobin (%A1C) prenatally and newborn %A1C and C-peptide values postnatally. Heart rate before and after birth and placental resistance prenatally were similar. Both normal and FODMs demonstrated an increase in left ventricular E/A and %E/E + A ratios from period 1 to 4 (p<0.0001). This shift occurred earlier (by period 2) in normals (p<0.01). Right ventricular filling ratios increased by period 4 in normals only (p<0.01). No differences were noted between the groups during any period. Good glycemic control in FODMs results in normal cardiac growth and ventricular diastolic filling. Progression of diastolic filling is abnormally delayed, however, and is presumably more exaggerated in poorly controlled diabetics.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalPediatric cardiology
Volume15
Issue number4
DOIs
StatePublished - Jul 1 1994

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Fetus
Mothers
Growth
Parturition
Doppler Echocardiography
C-Peptide
Hypertrophic Cardiomyopathy
Glycosylated Hemoglobin A
Birth Weight
Echocardiography
Heart Rate
Newborn Infant
Insulin

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Sequential longitudinal evaluation of cardiac growth and ventricular diastolic filling in fetuses of well controlled diabetic mothers",
abstract = "Hypertrophic cardiomyopathy and abnormal ventricular diastolic filling in the infant of the diabetic mother is related to poor maternal glycemic control. Evaluation of fetuses of well controlled diabetic mothers has not been examined. Eleven fetuses of nondiabetic mothers (normals) and 9 fetuses of well controlled insulin-dependent diabetic mothers (FODMs) under-went serial evaluation of cardiac growth and ventricular diastolic filling using M-mode and Doppler echocardiography at 20-26 weeks' (period 1), 27-33 weeks' (period 2), 34-40 weeks' (period 3), and 48-72 hours after birth (period 4). Indices of right and left ventricular diastolic filling included time velocity integral ratios (E/A and {\%}E/E + A). Cardiac growth and birth weight in the two groups were similar consistent with {"}good{"} glycemic control. This conclusion was supported by similar maternal glycosylated hemoglobin ({\%}A1C) prenatally and newborn {\%}A1C and C-peptide values postnatally. Heart rate before and after birth and placental resistance prenatally were similar. Both normal and FODMs demonstrated an increase in left ventricular E/A and {\%}E/E + A ratios from period 1 to 4 (p<0.0001). This shift occurred earlier (by period 2) in normals (p<0.01). Right ventricular filling ratios increased by period 4 in normals only (p<0.01). No differences were noted between the groups during any period. Good glycemic control in FODMs results in normal cardiac growth and ventricular diastolic filling. Progression of diastolic filling is abnormally delayed, however, and is presumably more exaggerated in poorly controlled diabetics.",
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Sequential longitudinal evaluation of cardiac growth and ventricular diastolic filling in fetuses of well controlled diabetic mothers. / Weber, Howard; Botti, J. J.; Baylen, B. G.

In: Pediatric cardiology, Vol. 15, No. 4, 01.07.1994, p. 184-189.

Research output: Contribution to journalArticle

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AB - Hypertrophic cardiomyopathy and abnormal ventricular diastolic filling in the infant of the diabetic mother is related to poor maternal glycemic control. Evaluation of fetuses of well controlled diabetic mothers has not been examined. Eleven fetuses of nondiabetic mothers (normals) and 9 fetuses of well controlled insulin-dependent diabetic mothers (FODMs) under-went serial evaluation of cardiac growth and ventricular diastolic filling using M-mode and Doppler echocardiography at 20-26 weeks' (period 1), 27-33 weeks' (period 2), 34-40 weeks' (period 3), and 48-72 hours after birth (period 4). Indices of right and left ventricular diastolic filling included time velocity integral ratios (E/A and %E/E + A). Cardiac growth and birth weight in the two groups were similar consistent with "good" glycemic control. This conclusion was supported by similar maternal glycosylated hemoglobin (%A1C) prenatally and newborn %A1C and C-peptide values postnatally. Heart rate before and after birth and placental resistance prenatally were similar. Both normal and FODMs demonstrated an increase in left ventricular E/A and %E/E + A ratios from period 1 to 4 (p<0.0001). This shift occurred earlier (by period 2) in normals (p<0.01). Right ventricular filling ratios increased by period 4 in normals only (p<0.01). No differences were noted between the groups during any period. Good glycemic control in FODMs results in normal cardiac growth and ventricular diastolic filling. Progression of diastolic filling is abnormally delayed, however, and is presumably more exaggerated in poorly controlled diabetics.

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