Sero-prevalence surveillance to predict vaccine-preventable disease outbreaks; A lesson from the 2014 measles epidemic in northern Vietnam

Marc Choisy, Trinh Son Tung, Nguyen Thi Ngoc Diep, Nguyen Tran Hien, Mai Quynh Le, Pham Quang Thai, Tran Nhu Duong, Dang Duc Anh, Peter W. Horby, Maciej F. Boni, Juliet Bryant, Sonia O. Lewycka, Behzad Nadjm, H. Rogier Van Doorn, Heiman F.L. Wertheim

Research output: Contribution to journalArticle

Abstract

Background. During the first half of 2014, a severe outbreak of measles occurred in northern Vietnam, causing 15 033 confirmed cases and 146 deaths. Methods. To evaluate the population-level seroprevalence of protection against measles in the period before the outbreak, we made use of an existing age-stratified serum bank, collected over the year before the outbreak, between November 2012 and December 2013, from 4 sites across the country (Hanoi, Hue, Dak Lak, and Ho Chi Minh City). Data from the UNICEF's Multiple Indicator Clustered Surveys (MICS), carried out in Vietnam during the first quarter of 2014, were used to assess the vaccine coverage in 6 ecological regions of Vietnam. Results. Results revealed a large discrepancy between levels of protection, as estimated from the serology and vaccine coverage estimated by UNICEF's MICS. Variation in seroprevalence across locations and age groups corresponded with reported numbers of measles cases, most of which were among the 0-2-year-old age group and in the northern part of the country. Conclusions. Our study presents a strong case in favor of a serosurveillance sentinel network that could be used to proactively tune vaccination policies and other public health interventions.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume6
Issue number3
DOIs
StatePublished - Mar 1 2019

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Vietnam
Measles
Disease Outbreaks
Vaccines
United Nations
Seroepidemiologic Studies
Age Groups
Serology
Vaccination
Public Health
Serum
Population
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

Cite this

Choisy, Marc ; Tung, Trinh Son ; Diep, Nguyen Thi Ngoc ; Hien, Nguyen Tran ; Le, Mai Quynh ; Thai, Pham Quang ; Duong, Tran Nhu ; Anh, Dang Duc ; Horby, Peter W. ; Boni, Maciej F. ; Bryant, Juliet ; Lewycka, Sonia O. ; Nadjm, Behzad ; Van Doorn, H. Rogier ; Wertheim, Heiman F.L. / Sero-prevalence surveillance to predict vaccine-preventable disease outbreaks; A lesson from the 2014 measles epidemic in northern Vietnam. In: Open Forum Infectious Diseases. 2019 ; Vol. 6, No. 3.
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title = "Sero-prevalence surveillance to predict vaccine-preventable disease outbreaks; A lesson from the 2014 measles epidemic in northern Vietnam",
abstract = "Background. During the first half of 2014, a severe outbreak of measles occurred in northern Vietnam, causing 15 033 confirmed cases and 146 deaths. Methods. To evaluate the population-level seroprevalence of protection against measles in the period before the outbreak, we made use of an existing age-stratified serum bank, collected over the year before the outbreak, between November 2012 and December 2013, from 4 sites across the country (Hanoi, Hue, Dak Lak, and Ho Chi Minh City). Data from the UNICEF's Multiple Indicator Clustered Surveys (MICS), carried out in Vietnam during the first quarter of 2014, were used to assess the vaccine coverage in 6 ecological regions of Vietnam. Results. Results revealed a large discrepancy between levels of protection, as estimated from the serology and vaccine coverage estimated by UNICEF's MICS. Variation in seroprevalence across locations and age groups corresponded with reported numbers of measles cases, most of which were among the 0-2-year-old age group and in the northern part of the country. Conclusions. Our study presents a strong case in favor of a serosurveillance sentinel network that could be used to proactively tune vaccination policies and other public health interventions.",
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Choisy, M, Tung, TS, Diep, NTN, Hien, NT, Le, MQ, Thai, PQ, Duong, TN, Anh, DD, Horby, PW, Boni, MF, Bryant, J, Lewycka, SO, Nadjm, B, Van Doorn, HR & Wertheim, HFL 2019, 'Sero-prevalence surveillance to predict vaccine-preventable disease outbreaks; A lesson from the 2014 measles epidemic in northern Vietnam', Open Forum Infectious Diseases, vol. 6, no. 3. https://doi.org/10.1093/ofid/ofz030

Sero-prevalence surveillance to predict vaccine-preventable disease outbreaks; A lesson from the 2014 measles epidemic in northern Vietnam. / Choisy, Marc; Tung, Trinh Son; Diep, Nguyen Thi Ngoc; Hien, Nguyen Tran; Le, Mai Quynh; Thai, Pham Quang; Duong, Tran Nhu; Anh, Dang Duc; Horby, Peter W.; Boni, Maciej F.; Bryant, Juliet; Lewycka, Sonia O.; Nadjm, Behzad; Van Doorn, H. Rogier; Wertheim, Heiman F.L.

In: Open Forum Infectious Diseases, Vol. 6, No. 3, 01.03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sero-prevalence surveillance to predict vaccine-preventable disease outbreaks; A lesson from the 2014 measles epidemic in northern Vietnam

AU - Choisy, Marc

AU - Tung, Trinh Son

AU - Diep, Nguyen Thi Ngoc

AU - Hien, Nguyen Tran

AU - Le, Mai Quynh

AU - Thai, Pham Quang

AU - Duong, Tran Nhu

AU - Anh, Dang Duc

AU - Horby, Peter W.

AU - Boni, Maciej F.

AU - Bryant, Juliet

AU - Lewycka, Sonia O.

AU - Nadjm, Behzad

AU - Van Doorn, H. Rogier

AU - Wertheim, Heiman F.L.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background. During the first half of 2014, a severe outbreak of measles occurred in northern Vietnam, causing 15 033 confirmed cases and 146 deaths. Methods. To evaluate the population-level seroprevalence of protection against measles in the period before the outbreak, we made use of an existing age-stratified serum bank, collected over the year before the outbreak, between November 2012 and December 2013, from 4 sites across the country (Hanoi, Hue, Dak Lak, and Ho Chi Minh City). Data from the UNICEF's Multiple Indicator Clustered Surveys (MICS), carried out in Vietnam during the first quarter of 2014, were used to assess the vaccine coverage in 6 ecological regions of Vietnam. Results. Results revealed a large discrepancy between levels of protection, as estimated from the serology and vaccine coverage estimated by UNICEF's MICS. Variation in seroprevalence across locations and age groups corresponded with reported numbers of measles cases, most of which were among the 0-2-year-old age group and in the northern part of the country. Conclusions. Our study presents a strong case in favor of a serosurveillance sentinel network that could be used to proactively tune vaccination policies and other public health interventions.

AB - Background. During the first half of 2014, a severe outbreak of measles occurred in northern Vietnam, causing 15 033 confirmed cases and 146 deaths. Methods. To evaluate the population-level seroprevalence of protection against measles in the period before the outbreak, we made use of an existing age-stratified serum bank, collected over the year before the outbreak, between November 2012 and December 2013, from 4 sites across the country (Hanoi, Hue, Dak Lak, and Ho Chi Minh City). Data from the UNICEF's Multiple Indicator Clustered Surveys (MICS), carried out in Vietnam during the first quarter of 2014, were used to assess the vaccine coverage in 6 ecological regions of Vietnam. Results. Results revealed a large discrepancy between levels of protection, as estimated from the serology and vaccine coverage estimated by UNICEF's MICS. Variation in seroprevalence across locations and age groups corresponded with reported numbers of measles cases, most of which were among the 0-2-year-old age group and in the northern part of the country. Conclusions. Our study presents a strong case in favor of a serosurveillance sentinel network that could be used to proactively tune vaccination policies and other public health interventions.

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