Serological inference of past primary and secondary dengue infection: Implications for vaccination

Ha Minh Lam, Huynh Thi Phuong, Nguyen Ha Thao Vy, Nguyen Thi Le Thanh, Pham Ngoc Dung, Thai Thi Ngoc Muon, Nguyen Van Vinh Chau, Isabel Rodríguez-Barraquer, Derek A.T. Cummings, Bridget A. Wills, Maciej F. Boni, Maia A. Rabaa, Hannah E. Clapham

Research output: Contribution to journalArticle

Abstract

Owing to the finding that Dengvaxia® (the only licensed dengue vaccine to date) increases the risk of severe illness among seronegative recipients, the World Health Organization has recommended screening individuals for their serostatus prior to vaccination. To decide whether and how to carry out screening, it is necessary to estimate the transmission intensity of dengue and to understand the performance of the screening method. In this study, we inferred the annual force of infection (FOI; a measurement of transmission intensity) of dengue virus in three locations in Vietnam: An Giang (FOI = 0.04 for the below 10 years age group and FOI = 0.20 for the above 10 years age group), Ho Chi Minh City (FOI = 0.12) and Quang Ngai (FOI = 0.05). In addition, we show that using a quantitative approach to immunoglobulin G (IgG) levels (measured by indirect enzyme-linked immunosorbent assays) can help to distinguish individuals with primary exposures (primary seropositive) from those with secondary exposures (secondary seropositive). We found that primary-seropositive individuals- the main targets of the vaccine-tend to have a lower IgG level, and, thus, they have a higher chance of being misclassified as seronegative than secondary-seropositive cases. However, screening performance can be improved by incorporating patient age and transmission intensity into the interpretation of IgG levels.

Original languageEnglish (US)
Article number20190207
JournalJournal of the Royal Society Interface
Volume16
Issue number156
DOIs
StatePublished - Jan 1 2019

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Dengue
Coinfection
Screening
Vaccination
Immunoglobulin G
Vaccines
Dengue Vaccines
Age Groups
Dengue Virus
Vietnam
Immunosorbents
Enzyme-Linked Immunosorbent Assay
Viruses
Assays
Enzymes
Health
Infection

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Lam, H. M., Phuong, H. T., Vy, N. H. T., Thanh, N. T. L., Dung, P. N., Muon, T. T. N., ... Clapham, H. E. (2019). Serological inference of past primary and secondary dengue infection: Implications for vaccination. Journal of the Royal Society Interface, 16(156), [20190207]. https://doi.org/10.1098/rsif.2019.0207
Lam, Ha Minh ; Phuong, Huynh Thi ; Vy, Nguyen Ha Thao ; Thanh, Nguyen Thi Le ; Dung, Pham Ngoc ; Muon, Thai Thi Ngoc ; Van Vinh Chau, Nguyen ; Rodríguez-Barraquer, Isabel ; Cummings, Derek A.T. ; Wills, Bridget A. ; Boni, Maciej F. ; Rabaa, Maia A. ; Clapham, Hannah E. / Serological inference of past primary and secondary dengue infection : Implications for vaccination. In: Journal of the Royal Society Interface. 2019 ; Vol. 16, No. 156.
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Lam, HM, Phuong, HT, Vy, NHT, Thanh, NTL, Dung, PN, Muon, TTN, Van Vinh Chau, N, Rodríguez-Barraquer, I, Cummings, DAT, Wills, BA, Boni, MF, Rabaa, MA & Clapham, HE 2019, 'Serological inference of past primary and secondary dengue infection: Implications for vaccination', Journal of the Royal Society Interface, vol. 16, no. 156, 20190207. https://doi.org/10.1098/rsif.2019.0207

Serological inference of past primary and secondary dengue infection : Implications for vaccination. / Lam, Ha Minh; Phuong, Huynh Thi; Vy, Nguyen Ha Thao; Thanh, Nguyen Thi Le; Dung, Pham Ngoc; Muon, Thai Thi Ngoc; Van Vinh Chau, Nguyen; Rodríguez-Barraquer, Isabel; Cummings, Derek A.T.; Wills, Bridget A.; Boni, Maciej F.; Rabaa, Maia A.; Clapham, Hannah E.

In: Journal of the Royal Society Interface, Vol. 16, No. 156, 20190207, 01.01.2019.

Research output: Contribution to journalArticle

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T1 - Serological inference of past primary and secondary dengue infection

T2 - Implications for vaccination

AU - Lam, Ha Minh

AU - Phuong, Huynh Thi

AU - Vy, Nguyen Ha Thao

AU - Thanh, Nguyen Thi Le

AU - Dung, Pham Ngoc

AU - Muon, Thai Thi Ngoc

AU - Van Vinh Chau, Nguyen

AU - Rodríguez-Barraquer, Isabel

AU - Cummings, Derek A.T.

AU - Wills, Bridget A.

AU - Boni, Maciej F.

AU - Rabaa, Maia A.

AU - Clapham, Hannah E.

PY - 2019/1/1

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N2 - Owing to the finding that Dengvaxia® (the only licensed dengue vaccine to date) increases the risk of severe illness among seronegative recipients, the World Health Organization has recommended screening individuals for their serostatus prior to vaccination. To decide whether and how to carry out screening, it is necessary to estimate the transmission intensity of dengue and to understand the performance of the screening method. In this study, we inferred the annual force of infection (FOI; a measurement of transmission intensity) of dengue virus in three locations in Vietnam: An Giang (FOI = 0.04 for the below 10 years age group and FOI = 0.20 for the above 10 years age group), Ho Chi Minh City (FOI = 0.12) and Quang Ngai (FOI = 0.05). In addition, we show that using a quantitative approach to immunoglobulin G (IgG) levels (measured by indirect enzyme-linked immunosorbent assays) can help to distinguish individuals with primary exposures (primary seropositive) from those with secondary exposures (secondary seropositive). We found that primary-seropositive individuals- the main targets of the vaccine-tend to have a lower IgG level, and, thus, they have a higher chance of being misclassified as seronegative than secondary-seropositive cases. However, screening performance can be improved by incorporating patient age and transmission intensity into the interpretation of IgG levels.

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