Serology and polymorphism of H-2L- locus encoded antigens

Chun Ming Huang, Huei Jen Su Huang, Jan Klein

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Abstract

Thirty B10.W congenic lines were analysed serologically, both by direct cytotoxicity and by absorption, for the presence of H-2L antigens. Three new H-2L antigens, 73, 74, and 75, were discovered. The B10.W lines and the inbred strains can be classified into at least six H-2L phenogroups on the basis of their reactivity with H- 2dm2anti-H- 2d serum: BALB/c, B10.BUA1, B10.GAA37, B10.BUA16. B10.KPB128, and the negative group. Twenty-one D-end recom-binants were analysed for the possible separation of H-2D and H-2L loci. The failure to find such a separation indicates that the H-2D and H-2L loci are tightly linked. Serological analysis also indicated that the H- 2dm1 has lost most of its H-2L antigens but retained at least one specificity which can be detected by H- 2dm2 anti -H- 2d serum.

Original languageEnglish (US)
Pages (from-to)173-182
Number of pages10
JournalImmunogenetics
Volume9
Issue number1
DOIs
StatePublished - Dec 1979

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

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    Huang, C. M., Huang, H. J. S., & Klein, J. (1979). Serology and polymorphism of H-2L- locus encoded antigens. Immunogenetics, 9(1), 173-182. https://doi.org/10.1007/BF01570408