Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone marrow failure consortium study

Susan Bell Nyland, Daniel J. Krissinger, Michael J. Clemente, Rosalyn B. Irby, Kendall Thomas Baab, Nancy Ruth Jarbadan, Lubomir Sokol, Eric Schaefer, Jason Liao, David Cuthbertson, Pearlie Epling-Burnette, Ronald Paquette, Alan F. List, Jaroslaw P. Maciejewski, Thomas P. Loughran

Research output: Contribution to journalArticle

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Abstract

Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human T-cell leukemia virus (HTLV) epitope, BA21. Aplastic anemia, paroxysmal nocturnal hemoglobinuria and myelodysplastic syndrome are bone marrow failure diseases that can also be associated with similar aberrant CTL activation (LGL-BMF). We identified a BA21 peptide that was specifically reactive with LGL leukemia sera and found significantly elevated antibody reactivity against the same peptide in LGL-BMF sera. This finding of shared seroreactivity in LGL-BMF conditions and LGL leukemia suggests that these diseases might share a common pathogenesis.

Original languageEnglish (US)
Pages (from-to)581-587
Number of pages7
JournalLeukemia Research
Volume36
Issue number5
DOIs
StatePublished - May 1 2012

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Large Granular Lymphocytic Leukemia
Paroxysmal Hemoglobinuria
Aplastic Anemia
Myelodysplastic Syndromes
Epitopes
Bone Marrow
Lymphocytes
Bone Marrow Diseases
Deltaretrovirus
T-Lymphocytes
Peptides
Serum
Antigens
Antibodies

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Nyland, Susan Bell ; Krissinger, Daniel J. ; Clemente, Michael J. ; Irby, Rosalyn B. ; Baab, Kendall Thomas ; Jarbadan, Nancy Ruth ; Sokol, Lubomir ; Schaefer, Eric ; Liao, Jason ; Cuthbertson, David ; Epling-Burnette, Pearlie ; Paquette, Ronald ; List, Alan F. ; Maciejewski, Jaroslaw P. ; Loughran, Thomas P. / Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria : Results of a bone marrow failure consortium study. In: Leukemia Research. 2012 ; Vol. 36, No. 5. pp. 581-587.
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abstract = "Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human T-cell leukemia virus (HTLV) epitope, BA21. Aplastic anemia, paroxysmal nocturnal hemoglobinuria and myelodysplastic syndrome are bone marrow failure diseases that can also be associated with similar aberrant CTL activation (LGL-BMF). We identified a BA21 peptide that was specifically reactive with LGL leukemia sera and found significantly elevated antibody reactivity against the same peptide in LGL-BMF sera. This finding of shared seroreactivity in LGL-BMF conditions and LGL leukemia suggests that these diseases might share a common pathogenesis.",
author = "Nyland, {Susan Bell} and Krissinger, {Daniel J.} and Clemente, {Michael J.} and Irby, {Rosalyn B.} and Baab, {Kendall Thomas} and Jarbadan, {Nancy Ruth} and Lubomir Sokol and Eric Schaefer and Jason Liao and David Cuthbertson and Pearlie Epling-Burnette and Ronald Paquette and List, {Alan F.} and Maciejewski, {Jaroslaw P.} and Loughran, {Thomas P.}",
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Nyland, SB, Krissinger, DJ, Clemente, MJ, Irby, RB, Baab, KT, Jarbadan, NR, Sokol, L, Schaefer, E, Liao, J, Cuthbertson, D, Epling-Burnette, P, Paquette, R, List, AF, Maciejewski, JP & Loughran, TP 2012, 'Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: Results of a bone marrow failure consortium study', Leukemia Research, vol. 36, no. 5, pp. 581-587. https://doi.org/10.1016/j.leukres.2012.02.001

Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria : Results of a bone marrow failure consortium study. / Nyland, Susan Bell; Krissinger, Daniel J.; Clemente, Michael J.; Irby, Rosalyn B.; Baab, Kendall Thomas; Jarbadan, Nancy Ruth; Sokol, Lubomir; Schaefer, Eric; Liao, Jason; Cuthbertson, David; Epling-Burnette, Pearlie; Paquette, Ronald; List, Alan F.; Maciejewski, Jaroslaw P.; Loughran, Thomas P.

In: Leukemia Research, Vol. 36, No. 5, 01.05.2012, p. 581-587.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria

T2 - Results of a bone marrow failure consortium study

AU - Nyland, Susan Bell

AU - Krissinger, Daniel J.

AU - Clemente, Michael J.

AU - Irby, Rosalyn B.

AU - Baab, Kendall Thomas

AU - Jarbadan, Nancy Ruth

AU - Sokol, Lubomir

AU - Schaefer, Eric

AU - Liao, Jason

AU - Cuthbertson, David

AU - Epling-Burnette, Pearlie

AU - Paquette, Ronald

AU - List, Alan F.

AU - Maciejewski, Jaroslaw P.

AU - Loughran, Thomas P.

PY - 2012/5/1

Y1 - 2012/5/1

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AB - Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human T-cell leukemia virus (HTLV) epitope, BA21. Aplastic anemia, paroxysmal nocturnal hemoglobinuria and myelodysplastic syndrome are bone marrow failure diseases that can also be associated with similar aberrant CTL activation (LGL-BMF). We identified a BA21 peptide that was specifically reactive with LGL leukemia sera and found significantly elevated antibody reactivity against the same peptide in LGL-BMF sera. This finding of shared seroreactivity in LGL-BMF conditions and LGL leukemia suggests that these diseases might share a common pathogenesis.

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