Serotonin signaling in diverticular disease

Meagan M. Costedio, Matthew Coates, Amy B. Danielson, Thomas R. Buttolph, Hagen J. Blaszyk, Gary M. Mawe, Neil H. Hyman

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Diverticulosis is extremely common in Western societies and is associated with complications in up to 15%of cases. Altered motility is an important feature of the pathogenesis of diverticular disease, and serotonin (5-HT) release is a primary trigger of gut motility. This study aims to determine whether colonic 5-HT signaling is altered in patients with diverticulosis or diverticulitis, and whether differences in serotonin signaling may distinguish patients with asymptomatic diverticulosis from those who develop disease specific complications. Sigmoid colon biopsies were obtained from healthy control subjects, individuals with asymptomatic diverticulosis, and those with a history of CT-proven diverticulitis within the preceding 6 months. The key elements of 5-HT signaling including content, release, and 5-HT transporter (SERT) expression were analyzed. A significant decrease in SERT transcript levels was present in the mucosa of patients with a history of diverticulitis when compared with controls, but not in those with asymptomatic diverticulosis. Mucosal 5-HT content, enterochromaffin (EC) cell numbers, and TpH-1 mRNA levels were comparable amongst the groups, as were basal and stimulated 5-HT release. Alterations in 5-HT signaling do not appear to be responsible for the development of diverticula. However, patients with a recent history of acute diverticulitis have a significant attenuation in SERT expression and function, likely secondary to previous inflammation. Our findings may explain the persistent symptoms of pain and altered motility so often observed in patients with diverticulitis long after recovery from the acute inflammatory response.

Original languageEnglish (US)
Pages (from-to)1439-1445
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2008

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Serotonin
Diverticulum
Diverticulitis
Enterochromaffin Cells
Sigmoid Colon
Healthy Volunteers
Mucous Membrane
Cell Count
Inflammation
Biopsy
Pain
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

Cite this

Costedio, M. M., Coates, M., Danielson, A. B., Buttolph, T. R., Blaszyk, H. J., Mawe, G. M., & Hyman, N. H. (2008). Serotonin signaling in diverticular disease. Journal of Gastrointestinal Surgery, 12(8), 1439-1445. https://doi.org/10.1007/s11605-008-0536-5
Costedio, Meagan M. ; Coates, Matthew ; Danielson, Amy B. ; Buttolph, Thomas R. ; Blaszyk, Hagen J. ; Mawe, Gary M. ; Hyman, Neil H. / Serotonin signaling in diverticular disease. In: Journal of Gastrointestinal Surgery. 2008 ; Vol. 12, No. 8. pp. 1439-1445.
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Costedio, MM, Coates, M, Danielson, AB, Buttolph, TR, Blaszyk, HJ, Mawe, GM & Hyman, NH 2008, 'Serotonin signaling in diverticular disease', Journal of Gastrointestinal Surgery, vol. 12, no. 8, pp. 1439-1445. https://doi.org/10.1007/s11605-008-0536-5

Serotonin signaling in diverticular disease. / Costedio, Meagan M.; Coates, Matthew; Danielson, Amy B.; Buttolph, Thomas R.; Blaszyk, Hagen J.; Mawe, Gary M.; Hyman, Neil H.

In: Journal of Gastrointestinal Surgery, Vol. 12, No. 8, 01.08.2008, p. 1439-1445.

Research output: Contribution to journalArticle

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AU - Costedio, Meagan M.

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Costedio MM, Coates M, Danielson AB, Buttolph TR, Blaszyk HJ, Mawe GM et al. Serotonin signaling in diverticular disease. Journal of Gastrointestinal Surgery. 2008 Aug 1;12(8):1439-1445. https://doi.org/10.1007/s11605-008-0536-5