Serum 2,3,7,8-tetrachloro-dibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses

Allan H. Smith, Donald George Jr Patterson, Marcella L. Warner, Ron Mackenzie, Larry L. Needham

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: The phenoxyherbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) has been widely used by professional pesticide applicators in New Zealand since before 1950. Epidemiologic studies of the risk of cancer and birth defects have been conducted in this group of workers, but little is known about the extent of their exposure to the 2,4,5-T contaminant 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), a potent carcinogen in animals., purpose: The objective of this study was to determine whether the blood serum levels of TCDD in a group of professional 2,4,5-T applicators in New Zealand were greater than those of a matched control group not involved in 2,4,5-T spraying. Methods: Of 548 men employed as professional pesticide applicators in New Zealand from 1979 through 1982, nine were selected who had sprayed pesticides, although not necessarily 2,4,5-T, for at least 180 months. These applicators had sprayed 2,4,5-T for a range of 83-372 months.We measured the blood serum levels of polychorinated dibenzo-p-dioxins and dibenzofurans, which were substituted with chlorine at the 2,3,7,8 position, in the nine pesticide applicators and in a matched group of nine control subjects. Results: The average serum level of TCDD for applicators was almost 10 times that for the matched control subjects, while the average levels of all other congeners and isomers measured in the two groups did not differ substantially. TCDD levels in eight of the nine applicators were higher than those in the control subjects (mean difference, 47.7 parts per trillion). The variation in TCDD levels among the applicators was related to their duration of work exposurs to 2,4,5-T. Conclusions: On the basis of our findings in these subjects in New Zealand, we conclude that increased risks of cancer from brief exposure to phenoxyher-bicides reported in other countries are probably not attributable to the TCDD that contaminates 2,4,5-T. We cannot determine from these results, however, whether TCDD exposure from prolonged use of 2,4,5-T poses significant health risks. [J Natl Cancer Inst 84: 104-108, 1992].

Original languageEnglish (US)
Pages (from-to)104-108
Number of pages5
JournalJournal of the National Cancer Institute
Volume84
Issue number2
DOIs
StatePublished - Jan 15 1992

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2,4,5-Trichlorophenoxyacetic Acid
New Zealand
Pesticides
Serum
Neoplasms
Research Design
dibenzo(1,4)dioxin
Chlorine
1,4-dioxin
Carcinogens
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Smith, Allan H. ; Patterson, Donald George Jr ; Warner, Marcella L. ; Mackenzie, Ron ; Needham, Larry L. / Serum 2,3,7,8-tetrachloro-dibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses. In: Journal of the National Cancer Institute. 1992 ; Vol. 84, No. 2. pp. 104-108.
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abstract = "Background: The phenoxyherbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) has been widely used by professional pesticide applicators in New Zealand since before 1950. Epidemiologic studies of the risk of cancer and birth defects have been conducted in this group of workers, but little is known about the extent of their exposure to the 2,4,5-T contaminant 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), a potent carcinogen in animals., purpose: The objective of this study was to determine whether the blood serum levels of TCDD in a group of professional 2,4,5-T applicators in New Zealand were greater than those of a matched control group not involved in 2,4,5-T spraying. Methods: Of 548 men employed as professional pesticide applicators in New Zealand from 1979 through 1982, nine were selected who had sprayed pesticides, although not necessarily 2,4,5-T, for at least 180 months. These applicators had sprayed 2,4,5-T for a range of 83-372 months.We measured the blood serum levels of polychorinated dibenzo-p-dioxins and dibenzofurans, which were substituted with chlorine at the 2,3,7,8 position, in the nine pesticide applicators and in a matched group of nine control subjects. Results: The average serum level of TCDD for applicators was almost 10 times that for the matched control subjects, while the average levels of all other congeners and isomers measured in the two groups did not differ substantially. TCDD levels in eight of the nine applicators were higher than those in the control subjects (mean difference, 47.7 parts per trillion). The variation in TCDD levels among the applicators was related to their duration of work exposurs to 2,4,5-T. Conclusions: On the basis of our findings in these subjects in New Zealand, we conclude that increased risks of cancer from brief exposure to phenoxyher-bicides reported in other countries are probably not attributable to the TCDD that contaminates 2,4,5-T. We cannot determine from these results, however, whether TCDD exposure from prolonged use of 2,4,5-T poses significant health risks. [J Natl Cancer Inst 84: 104-108, 1992].",
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Serum 2,3,7,8-tetrachloro-dibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses. / Smith, Allan H.; Patterson, Donald George Jr; Warner, Marcella L.; Mackenzie, Ron; Needham, Larry L.

In: Journal of the National Cancer Institute, Vol. 84, No. 2, 15.01.1992, p. 104-108.

Research output: Contribution to journalArticle

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T1 - Serum 2,3,7,8-tetrachloro-dibenzo-p-dioxin levels of New Zealand pesticide applicators and their implication for cancer hypotheses

AU - Smith, Allan H.

AU - Patterson, Donald George Jr

AU - Warner, Marcella L.

AU - Mackenzie, Ron

AU - Needham, Larry L.

PY - 1992/1/15

Y1 - 1992/1/15

N2 - Background: The phenoxyherbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) has been widely used by professional pesticide applicators in New Zealand since before 1950. Epidemiologic studies of the risk of cancer and birth defects have been conducted in this group of workers, but little is known about the extent of their exposure to the 2,4,5-T contaminant 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), a potent carcinogen in animals., purpose: The objective of this study was to determine whether the blood serum levels of TCDD in a group of professional 2,4,5-T applicators in New Zealand were greater than those of a matched control group not involved in 2,4,5-T spraying. Methods: Of 548 men employed as professional pesticide applicators in New Zealand from 1979 through 1982, nine were selected who had sprayed pesticides, although not necessarily 2,4,5-T, for at least 180 months. These applicators had sprayed 2,4,5-T for a range of 83-372 months.We measured the blood serum levels of polychorinated dibenzo-p-dioxins and dibenzofurans, which were substituted with chlorine at the 2,3,7,8 position, in the nine pesticide applicators and in a matched group of nine control subjects. Results: The average serum level of TCDD for applicators was almost 10 times that for the matched control subjects, while the average levels of all other congeners and isomers measured in the two groups did not differ substantially. TCDD levels in eight of the nine applicators were higher than those in the control subjects (mean difference, 47.7 parts per trillion). The variation in TCDD levels among the applicators was related to their duration of work exposurs to 2,4,5-T. Conclusions: On the basis of our findings in these subjects in New Zealand, we conclude that increased risks of cancer from brief exposure to phenoxyher-bicides reported in other countries are probably not attributable to the TCDD that contaminates 2,4,5-T. We cannot determine from these results, however, whether TCDD exposure from prolonged use of 2,4,5-T poses significant health risks. [J Natl Cancer Inst 84: 104-108, 1992].

AB - Background: The phenoxyherbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) has been widely used by professional pesticide applicators in New Zealand since before 1950. Epidemiologic studies of the risk of cancer and birth defects have been conducted in this group of workers, but little is known about the extent of their exposure to the 2,4,5-T contaminant 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD), a potent carcinogen in animals., purpose: The objective of this study was to determine whether the blood serum levels of TCDD in a group of professional 2,4,5-T applicators in New Zealand were greater than those of a matched control group not involved in 2,4,5-T spraying. Methods: Of 548 men employed as professional pesticide applicators in New Zealand from 1979 through 1982, nine were selected who had sprayed pesticides, although not necessarily 2,4,5-T, for at least 180 months. These applicators had sprayed 2,4,5-T for a range of 83-372 months.We measured the blood serum levels of polychorinated dibenzo-p-dioxins and dibenzofurans, which were substituted with chlorine at the 2,3,7,8 position, in the nine pesticide applicators and in a matched group of nine control subjects. Results: The average serum level of TCDD for applicators was almost 10 times that for the matched control subjects, while the average levels of all other congeners and isomers measured in the two groups did not differ substantially. TCDD levels in eight of the nine applicators were higher than those in the control subjects (mean difference, 47.7 parts per trillion). The variation in TCDD levels among the applicators was related to their duration of work exposurs to 2,4,5-T. Conclusions: On the basis of our findings in these subjects in New Zealand, we conclude that increased risks of cancer from brief exposure to phenoxyher-bicides reported in other countries are probably not attributable to the TCDD that contaminates 2,4,5-T. We cannot determine from these results, however, whether TCDD exposure from prolonged use of 2,4,5-T poses significant health risks. [J Natl Cancer Inst 84: 104-108, 1992].

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