Serum activin A does not predict ectopic pregnancy as a single measurement test, alone or as part of a multi-marker panel including progesterone and hCG

Joshua Warrick, Ann Gronowski, Courtney Moffett, Quihong Zhao, Emily Bishop, Alison Woodworth

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background: To evaluate the diagnostic accuracy of activin A alone or in a multi-marker panel for the prediction of ectopic pregnancy (EP). Methods: A retrospective analysis was performed on a cohort of 289 women who presented to the emergency department (ED) with vaginal bleeding and/or abdominal pain/cramping and were diagnosed with EP, spontaneous abortion, or viable intrauterine pregnancy. Serum progesterone, hCG, and activin A concentrations were measured on the samples obtained in the ED. Statistical analysis was performed to determine the clinical utility of these biomarkers as single measurement and as a multi-marker panel test for ectopic pregnancy. Women ≥ 18. y with vaginal bleeding or abdominal pain/cramping. Results: Progesterone (< 10. ng/ml), hCG (< 6,699. IU/l), and activin A (< 0.26. ng/ml) cutoffs were optimized by ROC analysis. These demonstrated sensitivities of 62.9%, 74.2%, and 59.6%, and specificities of 60.5%, and 63.0%, and 61.0% respectively for detecting EP. The multi-marker panel utilizing all three biomarkers had a sensitivity of 70% and specificity of 69%. Conclusion: Serum activin A cannot be used as a single measurement or in a multi-marker panel with progesterone and hCG to predict EP.

Original languageEnglish (US)
Pages (from-to)707-711
Number of pages5
JournalClinica Chimica Acta
Volume413
Issue number7-8
DOIs
StatePublished - Apr 11 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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