Serum dioxin concentrations and age at menarche

Marcella Warner, Steven Samuels, Paolo Mocarelli, Pier Mario Gerthoux, Larry Needham, Donald George Jr Patterson, Brenda Eskenazi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant, is associated with delays in pubertal development in animal studies. On 10 July 1976, as a result of a chemical explosion, residents of Seveso, Italy, experienced the highest levels of TCDD exposure experienced by a human population. Twenty years later, we initiated the Seveso Women's Health Study (SWHS), a retrospective cohort study of female residents of the most contaminated areas, to determine whether the women were at higher risk for reproductive disease. We examined the association of TCDD serum levels, based on measurements in serum collected soon after the explosion, with reported age at menarche among the 282 SWHS women who were premenarcheal at the time of the explosion. We found no change in risk of onset of menarche with a 10-fold increase in TCDD (e.g., 10-100 ppt; hazard ratio = 0.95; 95% confidence interval, 0.83-1.09; p-value for trend = 0.46). When TCDD levels were categorized, there was also no evidence of a dose-response trend (p = 0.65). In summary, we found that individual serum TCDD measurements are not significantly related to age at menarche among women in the SWHS cohort. The women in this study experienced substantial TCDD exposure during the postnatal but prepubertal developmental period. Given that animal evidence suggests in utero exposure has the most significant effect on onset of puberty, continued follow-up of the offspring of the SWHS cohort is important.

Original languageEnglish (US)
Pages (from-to)1289-1292
Number of pages4
JournalEnvironmental health perspectives
Volume112
Issue number13
DOIs
StatePublished - Sep 1 2004

Fingerprint

Menarche
Dioxins
dioxin
serum
womens health
Women's Health
Serum
Explosions
explosion
Cohort Studies
Animals
animal
Puberty
Polychlorinated Dibenzodioxins
1,4-dioxin
confidence interval
Italy
Hazards
Retrospective Studies
hazard

All Science Journal Classification (ASJC) codes

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Warner, M., Samuels, S., Mocarelli, P., Gerthoux, P. M., Needham, L., Patterson, D. G. J., & Eskenazi, B. (2004). Serum dioxin concentrations and age at menarche. Environmental health perspectives, 112(13), 1289-1292. https://doi.org/10.1289/ehp.7004
Warner, Marcella ; Samuels, Steven ; Mocarelli, Paolo ; Gerthoux, Pier Mario ; Needham, Larry ; Patterson, Donald George Jr ; Eskenazi, Brenda. / Serum dioxin concentrations and age at menarche. In: Environmental health perspectives. 2004 ; Vol. 112, No. 13. pp. 1289-1292.
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Warner, M, Samuels, S, Mocarelli, P, Gerthoux, PM, Needham, L, Patterson, DGJ & Eskenazi, B 2004, 'Serum dioxin concentrations and age at menarche', Environmental health perspectives, vol. 112, no. 13, pp. 1289-1292. https://doi.org/10.1289/ehp.7004

Serum dioxin concentrations and age at menarche. / Warner, Marcella; Samuels, Steven; Mocarelli, Paolo; Gerthoux, Pier Mario; Needham, Larry; Patterson, Donald George Jr; Eskenazi, Brenda.

In: Environmental health perspectives, Vol. 112, No. 13, 01.09.2004, p. 1289-1292.

Research output: Contribution to journalArticle

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AU - Warner, Marcella

AU - Samuels, Steven

AU - Mocarelli, Paolo

AU - Gerthoux, Pier Mario

AU - Needham, Larry

AU - Patterson, Donald George Jr

AU - Eskenazi, Brenda

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Warner M, Samuels S, Mocarelli P, Gerthoux PM, Needham L, Patterson DGJ et al. Serum dioxin concentrations and age at menarche. Environmental health perspectives. 2004 Sep 1;112(13):1289-1292. https://doi.org/10.1289/ehp.7004