Serum dioxins, polychlorinated biphenyls, and endometriosis: A case-control study in Atlanta

Amanda S. Niskar, Larry L. Needham, Carol Rubin, Wayman E. Turner, Colleen A. Martin, Donald George Jr Patterson, Lisa Hasty, Lee Yang Wong, Michele Marcus

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Abstract

Endometriosis among women of reproductive age can result in pain and infertility. The objectives of this study were to test if there is a relation between endometriosis and serum dioxin concentrations as expressed by total toxic equivalence and serum total polychlorinated biphenyl concentrations among women patients at one Atlanta reproductive medicine clinic during 1998-1999; a secondary objective was to provide exposure data for individual congeners of these chemicals and 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (p,p′-DDE) in women in Atlanta. Laparoscopy including biopsy and visualization of the peritoneal cavity, ovaries, outside of the fallopian tubes and uterus confirmed all endometriosis cases (n = 60) and confirmed 30 controls without endometriosis. Other controls had an infertile partner (n = 27) or ovulation problems (n = 7) with no signs or symptoms of endometriosis. All serum samples were analyzed at the U.S. Centers for Disease Control and Prevention in 2003. Statistical analyses included Fisher's exact chi-square tests and logistic regression. Models were presented for the full study sample and for the subset that included all cases (n = 60) and only controls (n = 30) with surgical confirmation of disease-free status. Serum concentrations (lipid-adjusted and non lipid-adjusted) of analyzed exposure measures were low and similar for cases and controls and did not explain endometriosis in the study population.

Original languageEnglish (US)
Pages (from-to)944-949
Number of pages6
JournalChemosphere
Volume74
Issue number7
DOIs
Publication statusPublished - Feb 1 2009

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All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Niskar, A. S., Needham, L. L., Rubin, C., Turner, W. E., Martin, C. A., Patterson, D. G. J., ... Marcus, M. (2009). Serum dioxins, polychlorinated biphenyls, and endometriosis: A case-control study in Atlanta. Chemosphere, 74(7), 944-949. https://doi.org/10.1016/j.chemosphere.2008.10.005