Serum dioxins, polychlorinated biphenyls, and endometriosis: A case-control study in Atlanta

Amanda S. Niskar, Larry L. Needham, Carol Rubin, Wayman E. Turner, Colleen A. Martin, Donald G. Patterson, Lisa Hasty, Lee Yang Wong, Michele Marcus

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Endometriosis among women of reproductive age can result in pain and infertility. The objectives of this study were to test if there is a relation between endometriosis and serum dioxin concentrations as expressed by total toxic equivalence and serum total polychlorinated biphenyl concentrations among women patients at one Atlanta reproductive medicine clinic during 1998-1999; a secondary objective was to provide exposure data for individual congeners of these chemicals and 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (p,p′-DDE) in women in Atlanta. Laparoscopy including biopsy and visualization of the peritoneal cavity, ovaries, outside of the fallopian tubes and uterus confirmed all endometriosis cases (n = 60) and confirmed 30 controls without endometriosis. Other controls had an infertile partner (n = 27) or ovulation problems (n = 7) with no signs or symptoms of endometriosis. All serum samples were analyzed at the U.S. Centers for Disease Control and Prevention in 2003. Statistical analyses included Fisher's exact chi-square tests and logistic regression. Models were presented for the full study sample and for the subset that included all cases (n = 60) and only controls (n = 30) with surgical confirmation of disease-free status. Serum concentrations (lipid-adjusted and non lipid-adjusted) of analyzed exposure measures were low and similar for cases and controls and did not explain endometriosis in the study population.

Original languageEnglish (US)
Pages (from-to)944-949
Number of pages6
JournalChemosphere
Volume74
Issue number7
DOIs
StatePublished - Feb 2009

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Chemistry(all)
  • Environmental Chemistry
  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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