Serum tocopherols, selenium and lung cancer risk among tin miners in China

Duminda Ratnasinghe, Joseph A. Tangrea, Michele R. Forman, Terryl Johnson Hartman, Elaine W. Gunter, You Lin Qiao, Shu Xiang Yao, Michael J. Barett, Carol A. Giffen, Yener Erozan, Melvyn S. Tockman, Philip R. Taylor

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the association of prediagnostic serum antioxidants and lung cancer risk we conducted a case-control study nested in an occupational cohort of tin miners. Methods: Male workers free of cancer enrolled in the cohort. During up to 6 years of follow-up, 339 lung cancer cases were diagnosed and, among these cases, those who donated blood prospectively (n = 108) were eligible for this study. For each case, two controls alive and free of cancer at the time of case diagnosis were matched on age and date of blood collection. Results: Overall, we observed no association between serum alpha-tocopherol, gamma-tocopherol or selenium levels and lung cancer risk. However, a significant gradient of decreasing lung cancer risk with increasing serum alpha-tocopherol was apparent for men less than 60 years old (odds ratio by tertile: 1.0, 0.9, 0.2; trend p = 0.002). Alpha-tocopherol was also protective in men who reported no alcohol drinking (OR by tertile: 1.0, 0.6, 0.3; trend p = 0.008). Conclusion: Although there were no significant overall associations between prospectively collected serum alpha-tocopherol, gamma-tocopherol or selenium and incidence of lung cancer, results from this study suggest that higher alpha-tocopherol levels may be protective in men less than 60 years old and in those who do not drink alcohol.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalCancer Causes and Control
Volume11
Issue number2
DOIs
StatePublished - Feb 23 2000

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Tocopherols
Tin
alpha-Tocopherol
Selenium
China
Lung Neoplasms
gamma-Tocopherol
Serum
Alcohol Drinking
Case-Control Studies
Neoplasms
Antioxidants
Odds Ratio
Alcohols
Miners
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ratnasinghe, D., Tangrea, J. A., Forman, M. R., Hartman, T. J., Gunter, E. W., Qiao, Y. L., ... Taylor, P. R. (2000). Serum tocopherols, selenium and lung cancer risk among tin miners in China. Cancer Causes and Control, 11(2), 129-135. https://doi.org/10.1023/A:1008977320811
Ratnasinghe, Duminda ; Tangrea, Joseph A. ; Forman, Michele R. ; Hartman, Terryl Johnson ; Gunter, Elaine W. ; Qiao, You Lin ; Yao, Shu Xiang ; Barett, Michael J. ; Giffen, Carol A. ; Erozan, Yener ; Tockman, Melvyn S. ; Taylor, Philip R. / Serum tocopherols, selenium and lung cancer risk among tin miners in China. In: Cancer Causes and Control. 2000 ; Vol. 11, No. 2. pp. 129-135.
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abstract = "Objective: To evaluate the association of prediagnostic serum antioxidants and lung cancer risk we conducted a case-control study nested in an occupational cohort of tin miners. Methods: Male workers free of cancer enrolled in the cohort. During up to 6 years of follow-up, 339 lung cancer cases were diagnosed and, among these cases, those who donated blood prospectively (n = 108) were eligible for this study. For each case, two controls alive and free of cancer at the time of case diagnosis were matched on age and date of blood collection. Results: Overall, we observed no association between serum alpha-tocopherol, gamma-tocopherol or selenium levels and lung cancer risk. However, a significant gradient of decreasing lung cancer risk with increasing serum alpha-tocopherol was apparent for men less than 60 years old (odds ratio by tertile: 1.0, 0.9, 0.2; trend p = 0.002). Alpha-tocopherol was also protective in men who reported no alcohol drinking (OR by tertile: 1.0, 0.6, 0.3; trend p = 0.008). Conclusion: Although there were no significant overall associations between prospectively collected serum alpha-tocopherol, gamma-tocopherol or selenium and incidence of lung cancer, results from this study suggest that higher alpha-tocopherol levels may be protective in men less than 60 years old and in those who do not drink alcohol.",
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Ratnasinghe, D, Tangrea, JA, Forman, MR, Hartman, TJ, Gunter, EW, Qiao, YL, Yao, SX, Barett, MJ, Giffen, CA, Erozan, Y, Tockman, MS & Taylor, PR 2000, 'Serum tocopherols, selenium and lung cancer risk among tin miners in China', Cancer Causes and Control, vol. 11, no. 2, pp. 129-135. https://doi.org/10.1023/A:1008977320811

Serum tocopherols, selenium and lung cancer risk among tin miners in China. / Ratnasinghe, Duminda; Tangrea, Joseph A.; Forman, Michele R.; Hartman, Terryl Johnson; Gunter, Elaine W.; Qiao, You Lin; Yao, Shu Xiang; Barett, Michael J.; Giffen, Carol A.; Erozan, Yener; Tockman, Melvyn S.; Taylor, Philip R.

In: Cancer Causes and Control, Vol. 11, No. 2, 23.02.2000, p. 129-135.

Research output: Contribution to journalArticle

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T1 - Serum tocopherols, selenium and lung cancer risk among tin miners in China

AU - Ratnasinghe, Duminda

AU - Tangrea, Joseph A.

AU - Forman, Michele R.

AU - Hartman, Terryl Johnson

AU - Gunter, Elaine W.

AU - Qiao, You Lin

AU - Yao, Shu Xiang

AU - Barett, Michael J.

AU - Giffen, Carol A.

AU - Erozan, Yener

AU - Tockman, Melvyn S.

AU - Taylor, Philip R.

PY - 2000/2/23

Y1 - 2000/2/23

N2 - Objective: To evaluate the association of prediagnostic serum antioxidants and lung cancer risk we conducted a case-control study nested in an occupational cohort of tin miners. Methods: Male workers free of cancer enrolled in the cohort. During up to 6 years of follow-up, 339 lung cancer cases were diagnosed and, among these cases, those who donated blood prospectively (n = 108) were eligible for this study. For each case, two controls alive and free of cancer at the time of case diagnosis were matched on age and date of blood collection. Results: Overall, we observed no association between serum alpha-tocopherol, gamma-tocopherol or selenium levels and lung cancer risk. However, a significant gradient of decreasing lung cancer risk with increasing serum alpha-tocopherol was apparent for men less than 60 years old (odds ratio by tertile: 1.0, 0.9, 0.2; trend p = 0.002). Alpha-tocopherol was also protective in men who reported no alcohol drinking (OR by tertile: 1.0, 0.6, 0.3; trend p = 0.008). Conclusion: Although there were no significant overall associations between prospectively collected serum alpha-tocopherol, gamma-tocopherol or selenium and incidence of lung cancer, results from this study suggest that higher alpha-tocopherol levels may be protective in men less than 60 years old and in those who do not drink alcohol.

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Ratnasinghe D, Tangrea JA, Forman MR, Hartman TJ, Gunter EW, Qiao YL et al. Serum tocopherols, selenium and lung cancer risk among tin miners in China. Cancer Causes and Control. 2000 Feb 23;11(2):129-135. https://doi.org/10.1023/A:1008977320811