Serum vitamin D and cognition in a cohort of Boston-area Puerto Ricans

Natalia Palacios, Tammy Scott, Neha Sahasrabudhe, Xiang Gao, Katherine L. Tucker

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Vitamin D has been suggested as a protective factor for cognitive health, however results of prior studies have been mixed. To examine whether serum 25(OH)D concentration is related to cognition and cognitive decline in a study of Boston Area Puerto Ricans. Methods: We examined the association between serum 25(OH)D, cognitive function and cognitive decline in a longitudinal study of 967 Boston Area Puerto Rican adults. Results: In analyses adjusted for potential confounders, participants in the bottom quintile of 25(OH)D had similar cognitive function at baseline, as measured by a global cognitive score (mean difference: 0.09 (95% CI: −0.02, 0.19); p-trend: 0.18), and similar 2-year rates of cognitive decline (mean difference: −0.01 (95% CI: −0.09, 0.07), p-trend: 0.61) as those in the top 25(OH)D quintile. No significant associations were observed between baseline serum 25(OH)D concentration and 2-year change in individual cognitive test scores or change in executive function or memory domains. Conclusions: We observed no significant association between serum 25(OH)D and cognition in this cohort of Boston Area Puerto Ricans.

Original languageEnglish (US)
Pages (from-to)688-695
Number of pages8
JournalNutritional Neuroscience
Issue number9
StatePublished - Sep 1 2020

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

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