Severe inhibitor-negative acquired factor XIII/13 deficiency with aggressive subdural haemorrhage

Hiroki Kawano, Daisuke Yamamoto, Yoshito Uchihashi, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Kentaro Minagawa, Yoshio Katayama, Eiji Kohmura, Masayoshi Souri, Akitada Ichinose

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acquired factor XIII (FXIII) deficiency is a common disease and seldom causes bleeding. However, severe FXIII deficiency may result in life-threatening bleeding. Although the inhibitor against FXIII has recently been focused as the cause of haemorrhagic acquired FXIII deficiency, the pathophysiology of inhibitor-negative cases could also be involved. We report a case of an 85-year-old Japanese man with serious subdural haemorrhage showing a remarkable decreased level of FXIII activity. He also manifested complications of compensated disseminated intravascular coagulation (DIC) with chronic renal failure, abdominal aortic aneurysm (AAA) and right renal carcinoma. Despite the successful evacuation of the haemorrhage, acute subdural haemorrhage subsequently developed that necessitated further craniotomies. Plasma cross-mixing studies and dot blot assay revealed no inhibitors against FXIII. We speculated that the decreased FXIII activity could be mainly due to hyperconsumption by DIC and surgery. Because plasma-derived FXIII concentrates are available to stop bleeding, clinicians should be aware of severe acquired inhibitor-negative FXIII deficiency in cases of unexplained excessive bleeding.

Original languageEnglish (US)
Pages (from-to)638-641
Number of pages4
JournalBlood Coagulation and Fibrinolysis
Volume24
Issue number6
DOIs
StatePublished - Sep 1 2013

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Factor XIII Deficiency
Factor XIII
Subdural Hematoma
Hemorrhage
Disseminated Intravascular Coagulation
Craniotomy
Abdominal Aortic Aneurysm
Chronic Kidney Failure
Carcinoma
Kidney

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Kawano, H., Yamamoto, D., Uchihashi, Y., Wakahashi, K., Kawano, Y., Sada, A., ... Ichinose, A. (2013). Severe inhibitor-negative acquired factor XIII/13 deficiency with aggressive subdural haemorrhage. Blood Coagulation and Fibrinolysis, 24(6), 638-641. https://doi.org/10.1097/MBC.0b013e32835facef
Kawano, Hiroki ; Yamamoto, Daisuke ; Uchihashi, Yoshito ; Wakahashi, Kanako ; Kawano, Yuko ; Sada, Akiko ; Minagawa, Kentaro ; Katayama, Yoshio ; Kohmura, Eiji ; Souri, Masayoshi ; Ichinose, Akitada. / Severe inhibitor-negative acquired factor XIII/13 deficiency with aggressive subdural haemorrhage. In: Blood Coagulation and Fibrinolysis. 2013 ; Vol. 24, No. 6. pp. 638-641.
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Kawano, H, Yamamoto, D, Uchihashi, Y, Wakahashi, K, Kawano, Y, Sada, A, Minagawa, K, Katayama, Y, Kohmura, E, Souri, M & Ichinose, A 2013, 'Severe inhibitor-negative acquired factor XIII/13 deficiency with aggressive subdural haemorrhage', Blood Coagulation and Fibrinolysis, vol. 24, no. 6, pp. 638-641. https://doi.org/10.1097/MBC.0b013e32835facef

Severe inhibitor-negative acquired factor XIII/13 deficiency with aggressive subdural haemorrhage. / Kawano, Hiroki; Yamamoto, Daisuke; Uchihashi, Yoshito; Wakahashi, Kanako; Kawano, Yuko; Sada, Akiko; Minagawa, Kentaro; Katayama, Yoshio; Kohmura, Eiji; Souri, Masayoshi; Ichinose, Akitada.

In: Blood Coagulation and Fibrinolysis, Vol. 24, No. 6, 01.09.2013, p. 638-641.

Research output: Contribution to journalArticle

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AU - Kawano, Yuko

AU - Sada, Akiko

AU - Minagawa, Kentaro

AU - Katayama, Yoshio

AU - Kohmura, Eiji

AU - Souri, Masayoshi

AU - Ichinose, Akitada

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