Abstract
Cw is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-Cw is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal Cw antibody. The medical literature relating to maternal Cw alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to Cw.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-217 |
| Number of pages | 5 |
| Journal | American Journal of Perinatology |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1 2006 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
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Severe neonatal hemolysis due to a maternal antibody to the low-frequency Rh antigen Cw. / May-Wewers, Julie; Kaiser, Jeffrey; Moore, Ellen Kay; Blackall, Douglas P.
In: American Journal of Perinatology, Vol. 23, No. 4, 01.05.2006, p. 213-217.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Severe neonatal hemolysis due to a maternal antibody to the low-frequency Rh antigen Cw
AU - May-Wewers, Julie
AU - Kaiser, Jeffrey
AU - Moore, Ellen Kay
AU - Blackall, Douglas P.
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Cw is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-Cw is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal Cw antibody. The medical literature relating to maternal Cw alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to Cw.
AB - Cw is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-Cw is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal Cw antibody. The medical literature relating to maternal Cw alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to Cw.
UR - http://www.scopus.com/inward/record.url?scp=33646489286&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646489286&partnerID=8YFLogxK
U2 - 10.1055/s-2006-934098
DO - 10.1055/s-2006-934098
M3 - Review article
C2 - 16596484
AN - SCOPUS:33646489286
VL - 23
SP - 213
EP - 217
JO - American Journal of Perinatology
JF - American Journal of Perinatology
SN - 0735-1631
IS - 4
ER -