Severe neonatal hemolysis due to a maternal antibody to the low-frequency Rh antigen Cw

Julie May-Wewers, Jeffrey Kaiser, Ellen Kay Moore, Douglas P. Blackall

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Cw is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-Cw is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal Cw antibody. The medical literature relating to maternal Cw alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to Cw.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalAmerican Journal of Perinatology
Volume23
Issue number4
DOIs
StatePublished - May 1 2006

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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