Severe obstructive sleep apnea-I: Onset, clinical course, and characteristics

Anthony Kales, Roger J. Cadieux, Edward Bixler, Constantin R. Soldatos, Antonio Vela-Bueno, Constantine A. Misoul, Todd W. Locke

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


The clinical course and characteristics of severe obstructive sleep apnea are described for 50 adults whose condition warranted recommendation for tracheostomy. All patients had a history of snoring, excessive daytime sleepiness and sleep attacks, nocturnal snorting and gasping sounds and observer-noted nocturnal breath cessations. Generally, these symptoms became manifest before age 40, their appearance tended to cluster together within only a few years and, invariably, they were chronic. Aside from snoring, excessive daytime sleepiness was on average often the first symptom and began at a mean age of 36 years. However, in half of the patients either hypertension or overweight preceded excessive daytime sleepiness by at least 1 year. Physicians in the office setting should suspect severe obstructive sleep apnea in patients who have loud snoring and either excessive daytime sleepiness, hypertension, or obesity. Further evidence of apnea can be obtained by determining the presence of the additional signs of loud nocturnal snorting and gasping sounds and nocturnal breath cessations.

Original languageEnglish (US)
Pages (from-to)419-425
Number of pages7
JournalJournal of Chronic Diseases
Issue number5
StatePublished - Jan 1 1985

All Science Journal Classification (ASJC) codes

  • Epidemiology


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