Objective: To evaluate pulmonary hypertension associated with acute motor sensory axonal neuropathy subtype of Guillain- Barre syndrome. Guillain-Barre syndrome consists of a group of autoimmune disorders that generally manifest as symmetric, progressive, ascending paralysis. There are five subtypes of Guillain- Barre syndrome, and autonomic involvement has been described in all subtypes, including cardiovascular, vasomotor, or pseudomotor dysfunction of both the sympathetic and parasympathetic systems. Design: Case report. Setting: Tertiary care pediatric intensive care unit. Patient: Three-yr-old female patient. Intervention: None. Measurements and Main Results: Serial measurements of pulmonary artery pressure. We report the case of a young girl with acute motor sensory axonal neuropathy who presented with severe cardiovascular collapse secondary to severe pulmonary hypertension. In this patient, multiple factors may have played a role in the development of pulmonary hypertension including autonomic dysfunction, hypoventilation, and immobility as a risk for thrombosis and pulmonary emboli. Conclusion: It is possible that many other individuals suffering from severe forms of Guillain-Barre syndrome, especially those with significant autonomic dysfunction, may actually have undiagnosed and therefore untreated pulmonary hypertension. Therefore, it is recommended that clinicians caring for critically ill children with Guillain-Barre syndrome have a high index of suspicion for pulmonary hypertension and consider echocardiography if there are clinical signs of this potentially fatal process.
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Critical Care and Intensive Care Medicine