Seveso Women's Health Study: Does zone of residence predict individual TCCD exposure?

Brenda Eskenazi, Paolo Mocarelli, Marcella Warner, Steven Samuels, Larry Needham, Donald Patterson, Paolo Brambilla, Pier Mario Gerthoux, Wayman Turner, Stefania Casalini, Mariangela Cazzaniga, Wan Ying Chee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is produced as an unwanted by-product of various chemical reactions and combustion processes, including the manufacture of chlorinated phenols and derivatives. In animals, TCDD exposure is associated with toxic, carcinogenic, developmental, and reproductive effects. In 1976, a chemical plant explosion in Seveso, Italy, exposed the residents in the surrounding community to the highest exposure to TCDD known in humans. Materials from an aerosol cloud of sodium hydroxide, sodium trichlorophenate and TCDD were deposited over an 18.1 km2 area. As evidence of the significant level of TCDD exposure, numerous animals died and 193 cases of chloracne were reported among residents of the area. Initially, the contaminated area was divided into three major exposure Zones (A, B, R) based on the concentration of TCDD in surface soils. To date, the majority of epidemiologic studies conducted in Seveso have used Zone of residence as a proxy measure of exposure. The purpose of the present study is to validate the use of Zone of residence in Seveso as a proxy measure of exposure against individual serum TCDD measurement, and to determine whether questionnaire information can improve the accuracy of the exposure classification. Using data collected from the Seveso Women's Health Study (SWHS), the first comprehensive epidemiologic study of the reproductive health of women in Seveso, we determined that Zone of residence is a good predictor of individual serum TCDD level, explaining 24% of the variance. Using questionnaire information could have improved prediction of individual exposure levels in Seveso, increasing the percent of the variation in serum TCDD levels explained to 42%.

Original languageEnglish (US)
Pages (from-to)937-942
Number of pages6
JournalChemosphere
Volume43
Issue number4-7
DOIs
StatePublished - May 16 2001

Fingerprint

womens health
Women's Health
dioxin
Animals
Sodium
Chemical plants
Phenols
Aerosols
Explosions
Byproducts
Chemical reactions
Health
Derivatives
Soils
serum
Proxy
Epidemiologic Studies
Chloracne
Serum
sodium

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Eskenazi, B., Mocarelli, P., Warner, M., Samuels, S., Needham, L., Patterson, D., ... Chee, W. Y. (2001). Seveso Women's Health Study: Does zone of residence predict individual TCCD exposure? Chemosphere, 43(4-7), 937-942. https://doi.org/10.1016/S0045-6535(00)00454-9
Eskenazi, Brenda ; Mocarelli, Paolo ; Warner, Marcella ; Samuels, Steven ; Needham, Larry ; Patterson, Donald ; Brambilla, Paolo ; Gerthoux, Pier Mario ; Turner, Wayman ; Casalini, Stefania ; Cazzaniga, Mariangela ; Chee, Wan Ying. / Seveso Women's Health Study : Does zone of residence predict individual TCCD exposure?. In: Chemosphere. 2001 ; Vol. 43, No. 4-7. pp. 937-942.
@article{10df7ccd33d24e0787317991f4d31731,
title = "Seveso Women's Health Study: Does zone of residence predict individual TCCD exposure?",
abstract = "The compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is produced as an unwanted by-product of various chemical reactions and combustion processes, including the manufacture of chlorinated phenols and derivatives. In animals, TCDD exposure is associated with toxic, carcinogenic, developmental, and reproductive effects. In 1976, a chemical plant explosion in Seveso, Italy, exposed the residents in the surrounding community to the highest exposure to TCDD known in humans. Materials from an aerosol cloud of sodium hydroxide, sodium trichlorophenate and TCDD were deposited over an 18.1 km2 area. As evidence of the significant level of TCDD exposure, numerous animals died and 193 cases of chloracne were reported among residents of the area. Initially, the contaminated area was divided into three major exposure Zones (A, B, R) based on the concentration of TCDD in surface soils. To date, the majority of epidemiologic studies conducted in Seveso have used Zone of residence as a proxy measure of exposure. The purpose of the present study is to validate the use of Zone of residence in Seveso as a proxy measure of exposure against individual serum TCDD measurement, and to determine whether questionnaire information can improve the accuracy of the exposure classification. Using data collected from the Seveso Women's Health Study (SWHS), the first comprehensive epidemiologic study of the reproductive health of women in Seveso, we determined that Zone of residence is a good predictor of individual serum TCDD level, explaining 24{\%} of the variance. Using questionnaire information could have improved prediction of individual exposure levels in Seveso, increasing the percent of the variation in serum TCDD levels explained to 42{\%}.",
author = "Brenda Eskenazi and Paolo Mocarelli and Marcella Warner and Steven Samuels and Larry Needham and Donald Patterson and Paolo Brambilla and Gerthoux, {Pier Mario} and Wayman Turner and Stefania Casalini and Mariangela Cazzaniga and Chee, {Wan Ying}",
year = "2001",
month = "5",
day = "16",
doi = "10.1016/S0045-6535(00)00454-9",
language = "English (US)",
volume = "43",
pages = "937--942",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier Limited",
number = "4-7",

}

Eskenazi, B, Mocarelli, P, Warner, M, Samuels, S, Needham, L, Patterson, D, Brambilla, P, Gerthoux, PM, Turner, W, Casalini, S, Cazzaniga, M & Chee, WY 2001, 'Seveso Women's Health Study: Does zone of residence predict individual TCCD exposure?', Chemosphere, vol. 43, no. 4-7, pp. 937-942. https://doi.org/10.1016/S0045-6535(00)00454-9

Seveso Women's Health Study : Does zone of residence predict individual TCCD exposure? / Eskenazi, Brenda; Mocarelli, Paolo; Warner, Marcella; Samuels, Steven; Needham, Larry; Patterson, Donald; Brambilla, Paolo; Gerthoux, Pier Mario; Turner, Wayman; Casalini, Stefania; Cazzaniga, Mariangela; Chee, Wan Ying.

In: Chemosphere, Vol. 43, No. 4-7, 16.05.2001, p. 937-942.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seveso Women's Health Study

T2 - Does zone of residence predict individual TCCD exposure?

AU - Eskenazi, Brenda

AU - Mocarelli, Paolo

AU - Warner, Marcella

AU - Samuels, Steven

AU - Needham, Larry

AU - Patterson, Donald

AU - Brambilla, Paolo

AU - Gerthoux, Pier Mario

AU - Turner, Wayman

AU - Casalini, Stefania

AU - Cazzaniga, Mariangela

AU - Chee, Wan Ying

PY - 2001/5/16

Y1 - 2001/5/16

N2 - The compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is produced as an unwanted by-product of various chemical reactions and combustion processes, including the manufacture of chlorinated phenols and derivatives. In animals, TCDD exposure is associated with toxic, carcinogenic, developmental, and reproductive effects. In 1976, a chemical plant explosion in Seveso, Italy, exposed the residents in the surrounding community to the highest exposure to TCDD known in humans. Materials from an aerosol cloud of sodium hydroxide, sodium trichlorophenate and TCDD were deposited over an 18.1 km2 area. As evidence of the significant level of TCDD exposure, numerous animals died and 193 cases of chloracne were reported among residents of the area. Initially, the contaminated area was divided into three major exposure Zones (A, B, R) based on the concentration of TCDD in surface soils. To date, the majority of epidemiologic studies conducted in Seveso have used Zone of residence as a proxy measure of exposure. The purpose of the present study is to validate the use of Zone of residence in Seveso as a proxy measure of exposure against individual serum TCDD measurement, and to determine whether questionnaire information can improve the accuracy of the exposure classification. Using data collected from the Seveso Women's Health Study (SWHS), the first comprehensive epidemiologic study of the reproductive health of women in Seveso, we determined that Zone of residence is a good predictor of individual serum TCDD level, explaining 24% of the variance. Using questionnaire information could have improved prediction of individual exposure levels in Seveso, increasing the percent of the variation in serum TCDD levels explained to 42%.

AB - The compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is produced as an unwanted by-product of various chemical reactions and combustion processes, including the manufacture of chlorinated phenols and derivatives. In animals, TCDD exposure is associated with toxic, carcinogenic, developmental, and reproductive effects. In 1976, a chemical plant explosion in Seveso, Italy, exposed the residents in the surrounding community to the highest exposure to TCDD known in humans. Materials from an aerosol cloud of sodium hydroxide, sodium trichlorophenate and TCDD were deposited over an 18.1 km2 area. As evidence of the significant level of TCDD exposure, numerous animals died and 193 cases of chloracne were reported among residents of the area. Initially, the contaminated area was divided into three major exposure Zones (A, B, R) based on the concentration of TCDD in surface soils. To date, the majority of epidemiologic studies conducted in Seveso have used Zone of residence as a proxy measure of exposure. The purpose of the present study is to validate the use of Zone of residence in Seveso as a proxy measure of exposure against individual serum TCDD measurement, and to determine whether questionnaire information can improve the accuracy of the exposure classification. Using data collected from the Seveso Women's Health Study (SWHS), the first comprehensive epidemiologic study of the reproductive health of women in Seveso, we determined that Zone of residence is a good predictor of individual serum TCDD level, explaining 24% of the variance. Using questionnaire information could have improved prediction of individual exposure levels in Seveso, increasing the percent of the variation in serum TCDD levels explained to 42%.

UR - http://www.scopus.com/inward/record.url?scp=0035036057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035036057&partnerID=8YFLogxK

U2 - 10.1016/S0045-6535(00)00454-9

DO - 10.1016/S0045-6535(00)00454-9

M3 - Article

C2 - 11372887

AN - SCOPUS:0035036057

VL - 43

SP - 937

EP - 942

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 4-7

ER -

Eskenazi B, Mocarelli P, Warner M, Samuels S, Needham L, Patterson D et al. Seveso Women's Health Study: Does zone of residence predict individual TCCD exposure? Chemosphere. 2001 May 16;43(4-7):937-942. https://doi.org/10.1016/S0045-6535(00)00454-9