Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

Tracey L. Papenfuss, Connie J. Rogers, Ingrid Gienapp, Maria Yurrita, Melanie McClain, Nicole Damico, Janie Valo, Fei Song, Caroline C. Whitacre

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalJournal of Neuroimmunology
Volume150
Issue number1-2
DOIs
StatePublished - May 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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