Sex differences in forearm vasoconstrictor response to voluntary apnea

Hardikkumar M. Patel, Matthew J. Heffernan, Amanda J. Ross, Matthew D. Muller

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Clinical evidence indicates that obstructive sleep apnea is more common and more severe in men compared with women. Sex differences in the vasoconstrictor response to hypoxemia-induced sympathetic activation might contribute to this clinical observation. In the current laboratory study, we determined sex differences in the acute physiological responses to maximal voluntary end-expiratory apnea (MVEEA) during wakefulness in healthy young men and women (26 ± 1 yr) as well as healthy older men and women (64 ± 2 yr). Mean arterial pressure (MAP), heart rate (HR), brachial artery blood flow velocity (BBFV, Doppler ultrasound), and cutaneous vascular conductance (CVC, laser Doppler flowmetry) were measured, and changes in physiological parameters from baseline were compared between groups. The breath-hold duration and oxygen-saturation nadir were similar between groups. In response to MVEEA, young women had significantly less forearm vasoconstriction compared with young men (ΔBBFV: 2 ± 7 vs. -25 ± 6% and ΔCVC: -5 ± 4 vs. -31 ± 4%), whereas ΔMAP (12 ± 2 vs. 16 ± 3 mmHg) and ΔHR (4 ± 2 vs. 6 ± 3 bpm) were comparable between groups. The attenuated forearm vasoconstriction in young women was not observed in postmenopausal women (ΔBBFV -21 ± 5%). We concluded that young women have blunted forearm vasoconstriction in response to MVEEA compared with young men, and this effect is not evident in older postmenopausal women. These data suggest that female sex hormones dampen neurogenic vasoconstriction in response to apnea-induced hypoxemia.

Original languageEnglish (US)
Pages (from-to)H309-H316
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume306
Issue number3
DOIs
StatePublished - Feb 1 2014

Fingerprint

Vasoconstrictor Agents
Apnea
Forearm
Sex Characteristics
Vasoconstriction
Arterial Pressure
Heart Rate
Doppler Ultrasonography
Laser-Doppler Flowmetry
Brachial Artery
Blood Flow Velocity
Wakefulness
Gonadal Steroid Hormones
Obstructive Sleep Apnea
Blood Vessels
Observation
Oxygen
Skin

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Patel, Hardikkumar M. ; Heffernan, Matthew J. ; Ross, Amanda J. ; Muller, Matthew D. / Sex differences in forearm vasoconstrictor response to voluntary apnea. In: American Journal of Physiology - Heart and Circulatory Physiology. 2014 ; Vol. 306, No. 3. pp. H309-H316.
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Sex differences in forearm vasoconstrictor response to voluntary apnea. / Patel, Hardikkumar M.; Heffernan, Matthew J.; Ross, Amanda J.; Muller, Matthew D.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 306, No. 3, 01.02.2014, p. H309-H316.

Research output: Contribution to journalArticle

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AB - Clinical evidence indicates that obstructive sleep apnea is more common and more severe in men compared with women. Sex differences in the vasoconstrictor response to hypoxemia-induced sympathetic activation might contribute to this clinical observation. In the current laboratory study, we determined sex differences in the acute physiological responses to maximal voluntary end-expiratory apnea (MVEEA) during wakefulness in healthy young men and women (26 ± 1 yr) as well as healthy older men and women (64 ± 2 yr). Mean arterial pressure (MAP), heart rate (HR), brachial artery blood flow velocity (BBFV, Doppler ultrasound), and cutaneous vascular conductance (CVC, laser Doppler flowmetry) were measured, and changes in physiological parameters from baseline were compared between groups. The breath-hold duration and oxygen-saturation nadir were similar between groups. In response to MVEEA, young women had significantly less forearm vasoconstriction compared with young men (ΔBBFV: 2 ± 7 vs. -25 ± 6% and ΔCVC: -5 ± 4 vs. -31 ± 4%), whereas ΔMAP (12 ± 2 vs. 16 ± 3 mmHg) and ΔHR (4 ± 2 vs. 6 ± 3 bpm) were comparable between groups. The attenuated forearm vasoconstriction in young women was not observed in postmenopausal women (ΔBBFV -21 ± 5%). We concluded that young women have blunted forearm vasoconstriction in response to MVEEA compared with young men, and this effect is not evident in older postmenopausal women. These data suggest that female sex hormones dampen neurogenic vasoconstriction in response to apnea-induced hypoxemia.

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