Sex differences in resting state brain function of cigarette smokers and links to nicotine dependence

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Sex-a marker of biological and social individual differences-matters for drug use, particularly for cigarette smoking, which is the leading cause of preventable death in the United States. More men than women smoke, but women are less likely than men to quit. Resting state brain function, or intrinsic brain activity that occurs in the absence of a goal-directed task, is important for understanding cigarette smoking, as it has been shown to differentiate between smokers and nonsmokers. But, it is unclear whether and how sex influences the link between resting state brain function and smoking behavior. In this study, the authors demonstrate that sex is indeed associated with resting state connectivity in cigarette smokers, and that sex moderates the link between resting state connectivity and self-reported nicotine dependence. Using functional MRI and behavioral data from 50 adult daily smokers (23 women), the authors found that women had greater connectivity than men within the default mode network, and that increased connectivity within the reward network was related to increased nicotine tolerance in women but to decreased nicotine tolerance in men. Findings highlight the importance of sex-related individual differences reflected in resting state connectivity for understanding the etiology and treatment of substance use problems.

Original languageEnglish (US)
Pages (from-to)247-254
Number of pages8
JournalExperimental and clinical psychopharmacology
Volume23
Issue number4
DOIs
StatePublished - Aug 1 2015

Fingerprint

Tobacco Use Disorder
Tobacco Products
Sex Characteristics
Brain
Smoking
Nicotine
Individuality
Reward
Smoke
Cause of Death
Biomarkers
Magnetic Resonance Imaging
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

@article{5d5c488e0a2344eb92e1fa420b925d12,
title = "Sex differences in resting state brain function of cigarette smokers and links to nicotine dependence",
abstract = "Sex-a marker of biological and social individual differences-matters for drug use, particularly for cigarette smoking, which is the leading cause of preventable death in the United States. More men than women smoke, but women are less likely than men to quit. Resting state brain function, or intrinsic brain activity that occurs in the absence of a goal-directed task, is important for understanding cigarette smoking, as it has been shown to differentiate between smokers and nonsmokers. But, it is unclear whether and how sex influences the link between resting state brain function and smoking behavior. In this study, the authors demonstrate that sex is indeed associated with resting state connectivity in cigarette smokers, and that sex moderates the link between resting state connectivity and self-reported nicotine dependence. Using functional MRI and behavioral data from 50 adult daily smokers (23 women), the authors found that women had greater connectivity than men within the default mode network, and that increased connectivity within the reward network was related to increased nicotine tolerance in women but to decreased nicotine tolerance in men. Findings highlight the importance of sex-related individual differences reflected in resting state connectivity for understanding the etiology and treatment of substance use problems.",
author = "Beltz, {Adriene M.} and Berenbaum, {Sheri A.} and Wilson, {Stephen J.}",
year = "2015",
month = "8",
day = "1",
doi = "10.1037/pha0000033",
language = "English (US)",
volume = "23",
pages = "247--254",
journal = "Experimental and Clinical Psychopharmacology",
issn = "1064-1297",
publisher = "American Psychological Association Inc.",
number = "4",

}

TY - JOUR

T1 - Sex differences in resting state brain function of cigarette smokers and links to nicotine dependence

AU - Beltz, Adriene M.

AU - Berenbaum, Sheri A.

AU - Wilson, Stephen J.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Sex-a marker of biological and social individual differences-matters for drug use, particularly for cigarette smoking, which is the leading cause of preventable death in the United States. More men than women smoke, but women are less likely than men to quit. Resting state brain function, or intrinsic brain activity that occurs in the absence of a goal-directed task, is important for understanding cigarette smoking, as it has been shown to differentiate between smokers and nonsmokers. But, it is unclear whether and how sex influences the link between resting state brain function and smoking behavior. In this study, the authors demonstrate that sex is indeed associated with resting state connectivity in cigarette smokers, and that sex moderates the link between resting state connectivity and self-reported nicotine dependence. Using functional MRI and behavioral data from 50 adult daily smokers (23 women), the authors found that women had greater connectivity than men within the default mode network, and that increased connectivity within the reward network was related to increased nicotine tolerance in women but to decreased nicotine tolerance in men. Findings highlight the importance of sex-related individual differences reflected in resting state connectivity for understanding the etiology and treatment of substance use problems.

AB - Sex-a marker of biological and social individual differences-matters for drug use, particularly for cigarette smoking, which is the leading cause of preventable death in the United States. More men than women smoke, but women are less likely than men to quit. Resting state brain function, or intrinsic brain activity that occurs in the absence of a goal-directed task, is important for understanding cigarette smoking, as it has been shown to differentiate between smokers and nonsmokers. But, it is unclear whether and how sex influences the link between resting state brain function and smoking behavior. In this study, the authors demonstrate that sex is indeed associated with resting state connectivity in cigarette smokers, and that sex moderates the link between resting state connectivity and self-reported nicotine dependence. Using functional MRI and behavioral data from 50 adult daily smokers (23 women), the authors found that women had greater connectivity than men within the default mode network, and that increased connectivity within the reward network was related to increased nicotine tolerance in women but to decreased nicotine tolerance in men. Findings highlight the importance of sex-related individual differences reflected in resting state connectivity for understanding the etiology and treatment of substance use problems.

UR - http://www.scopus.com/inward/record.url?scp=84938562426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938562426&partnerID=8YFLogxK

U2 - 10.1037/pha0000033

DO - 10.1037/pha0000033

M3 - Article

C2 - 26237322

AN - SCOPUS:84938562426

VL - 23

SP - 247

EP - 254

JO - Experimental and Clinical Psychopharmacology

JF - Experimental and Clinical Psychopharmacology

SN - 1064-1297

IS - 4

ER -