Sex differences in salivary cortisol levels following naltrexone administration

Laura Klein, Larry D. Jamner, Janel Alberts, Matthew D. Orenstein, Linda Levine, Hoyle Leigh

Research output: Contribution to journalArticle

Abstract

Effects of endogenous opioid peptide blockade by naltrexone on salivary cortisol levels were examined in healthy men (n = 8) and women (n = 6). Participants received naltrexone (100 mg) during one laboratory session and a placebo pill during another session. Drug order was counterbalanced across participants. Saliva samples were collected 24 hr after each pill was administered. Among women, salivary cortisol levels significantly increased following naltrexone administration compared with a placebo pill. Naltrexone administration did not alter salivary cortisol levels in men. Results suggest sex differences in neuroendocrine sensitivity to opioid blockade, a finding that may hold significance with regard to the treatment of alcohol addiction with naltrexone.

Original languageEnglish (US)
Pages (from-to)144-153
Number of pages10
JournalInternational Journal of Fracture
Volume100
Issue number4
StatePublished - Dec 1 1999

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Opioids
Cortisol
Alcohol
Peptides
Drugs
Alcohols

All Science Journal Classification (ASJC) codes

  • Computational Mechanics
  • Modeling and Simulation
  • Mechanics of Materials

Cite this

Klein, L., Jamner, L. D., Alberts, J., Orenstein, M. D., Levine, L., & Leigh, H. (1999). Sex differences in salivary cortisol levels following naltrexone administration. International Journal of Fracture, 100(4), 144-153.
Klein, Laura ; Jamner, Larry D. ; Alberts, Janel ; Orenstein, Matthew D. ; Levine, Linda ; Leigh, Hoyle. / Sex differences in salivary cortisol levels following naltrexone administration. In: International Journal of Fracture. 1999 ; Vol. 100, No. 4. pp. 144-153.
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Klein, L, Jamner, LD, Alberts, J, Orenstein, MD, Levine, L & Leigh, H 1999, 'Sex differences in salivary cortisol levels following naltrexone administration', International Journal of Fracture, vol. 100, no. 4, pp. 144-153.

Sex differences in salivary cortisol levels following naltrexone administration. / Klein, Laura; Jamner, Larry D.; Alberts, Janel; Orenstein, Matthew D.; Levine, Linda; Leigh, Hoyle.

In: International Journal of Fracture, Vol. 100, No. 4, 01.12.1999, p. 144-153.

Research output: Contribution to journalArticle

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Klein L, Jamner LD, Alberts J, Orenstein MD, Levine L, Leigh H. Sex differences in salivary cortisol levels following naltrexone administration. International Journal of Fracture. 1999 Dec 1;100(4):144-153.