Sex-specific influence of aging on exercising leg blood flow

Beth A. Parker, Sandra L. Smithmyer, Justin A. Pelberg, Aaron D. Mishkin, David Nathan Proctor

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Our previous work suggests that healthy human aging is associated with sex-specific differences in leg vascular responses during large muscle mass exercise (2-legged cycling) (Proctor DN, Parker BA. Microcirculation 13: 315-327, 2006). The present study determined whether age X sex interactions in exercising leg hemodynamics persist during small muscle mass exercise that is not limited by cardiac output. Thirty-one young (20-30 yr; 15 men/16 women) and 31 older (60-79 yr; 13 men/18 women) healthy, normally active adults performed graded single-leg knee extensions to maximal exertion. Femoral artery blood velocity and diameter (Doppler ultrasound), heart rate (ECG), and beat-to-beat arterial blood pressure (mean arterial pressure, radial artery tonometry) were measured during each 3-min work rate (4.8 and 8 W/stage for women and men, respectively). The results (means ± SE) were as follows. Despite reduced resting leg blood flow and vascular conductance, older men exhibited relatively preserved exercising leg hemodynamic responses. Older women, by contrast, exhibited attenuated hyperemic (young: 52 ± 3 ml·min -1·W-1; vs. older: 40 ± 4 ml·min -1·W-1; P = 0.02) and vasodilatory responses (young: 0.56 ± 0.06 ml·min-1·mmHg -1·W-1 vs. older: 0.37 ± 0.04 ml·min-1·mmHg-1 W-1; P < 0.01) to exercise compared with young women. Relative (percentage of maximal) work rate comparisons of all groups combined also revealed attenuated vasodilator responses in older women (P < 0.01 for age X sex X work rate interaction). These sex-specific age differences were not abolished by consideration of hemoglobin, quadriceps muscle, muscle recruitment, and mechanical influences on muscle perfusion. Collectively, these findings suggest that local factors contribute to the sex-specific effects of aging on exercising leg hemodynamics in healthy adults.

Original languageEnglish (US)
Pages (from-to)655-664
Number of pages10
JournalJournal of applied physiology
Volume104
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Leg
Muscles
Hemodynamics
Exercise
Blood Vessels
Arterial Pressure
Doppler Ultrasonography
Radial Artery
Quadriceps Muscle
Manometry
Femoral Artery
Microcirculation
Vasodilator Agents
Sex Characteristics
Cardiac Output
Knee
Electrocardiography
Hemoglobins
Perfusion
Heart Rate

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Parker, Beth A. ; Smithmyer, Sandra L. ; Pelberg, Justin A. ; Mishkin, Aaron D. ; Proctor, David Nathan. / Sex-specific influence of aging on exercising leg blood flow. In: Journal of applied physiology. 2008 ; Vol. 104, No. 3. pp. 655-664.
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abstract = "Our previous work suggests that healthy human aging is associated with sex-specific differences in leg vascular responses during large muscle mass exercise (2-legged cycling) (Proctor DN, Parker BA. Microcirculation 13: 315-327, 2006). The present study determined whether age X sex interactions in exercising leg hemodynamics persist during small muscle mass exercise that is not limited by cardiac output. Thirty-one young (20-30 yr; 15 men/16 women) and 31 older (60-79 yr; 13 men/18 women) healthy, normally active adults performed graded single-leg knee extensions to maximal exertion. Femoral artery blood velocity and diameter (Doppler ultrasound), heart rate (ECG), and beat-to-beat arterial blood pressure (mean arterial pressure, radial artery tonometry) were measured during each 3-min work rate (4.8 and 8 W/stage for women and men, respectively). The results (means ± SE) were as follows. Despite reduced resting leg blood flow and vascular conductance, older men exhibited relatively preserved exercising leg hemodynamic responses. Older women, by contrast, exhibited attenuated hyperemic (young: 52 ± 3 ml·min -1·W-1; vs. older: 40 ± 4 ml·min -1·W-1; P = 0.02) and vasodilatory responses (young: 0.56 ± 0.06 ml·min-1·mmHg -1·W-1 vs. older: 0.37 ± 0.04 ml·min-1·mmHg-1 W-1; P < 0.01) to exercise compared with young women. Relative (percentage of maximal) work rate comparisons of all groups combined also revealed attenuated vasodilator responses in older women (P < 0.01 for age X sex X work rate interaction). These sex-specific age differences were not abolished by consideration of hemoglobin, quadriceps muscle, muscle recruitment, and mechanical influences on muscle perfusion. Collectively, these findings suggest that local factors contribute to the sex-specific effects of aging on exercising leg hemodynamics in healthy adults.",
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Sex-specific influence of aging on exercising leg blood flow. / Parker, Beth A.; Smithmyer, Sandra L.; Pelberg, Justin A.; Mishkin, Aaron D.; Proctor, David Nathan.

In: Journal of applied physiology, Vol. 104, No. 3, 01.03.2008, p. 655-664.

Research output: Contribution to journalArticle

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