Shape vs. volume: Invariant shape descriptors for 3D region of interest characterization in MRI

S. Tootoonian, R. Abugharbieh, Xuemei Huang, M. J. McKeown

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

We propose a new approach for quantifying regions of interest (ROIs) in medical image data. Rotationally invariant shape descriptors (ISDs) were applied to 3D brain regions extracted from MRI scans of 5 Parkinson's patients and 10 control subjects. We concentrated on the thalamus and the caudate nucleus since prior studies have suggested they are affected in Parkinson's disease (PD). In the caudate, both the ISD and volumetric analyses found significant differences between control and PD subjects. The ISD analysis however revealed additional differences between the left and right caudate nuclei in both control and PD subjects. In the thalamus, the volumetric analysis showed significant differences between PD and control subjects, while ISD analysis found significant differences between the left and right thalami in control subjects but not in PD patients, implying disease-induced shape changes. These results suggest that employing ISDs for ROI characterization both complements and extends traditional volumetric analyses.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages754-757
Number of pages4
StatePublished - Nov 17 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Publication series

Name2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

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All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Tootoonian, S., Abugharbieh, R., Huang, X., & McKeown, M. J. (2006). Shape vs. volume: Invariant shape descriptors for 3D region of interest characterization in MRI. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 754-757). [162526] (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006).