Shared class II MHC polymorphisms between humans and chimpanzees

Weimin Fan, Masanori Kasahara, Jutta Gutknecht, Dagmar Klein, Werner E. Mayer, Margreet Jonker, Jan Klein

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

To gain an insight into the evolution of the major histocompatibility complex alleles, three DRB and one DRA genes were isolated from chimpanzee cDNA libraries. The nucleotide sequences of the chimpanzee DRB (ChLA-DRB) genes were then compared with those of the available HLA-DRB alleles by constructing unrooted phylogenetic trees. All three ChLA-DRB genes were found to be more closely related to certain HLA-DRB alleles than unrelated HLA-DRB alleles are to each other. Since available evidence does not support the convergent evolution of MHC alleles, this result is consistent with the idea that closely related ChLA-DRB and HLA-DRB alleles are derived from common ancestral alleles, the existence of which predates the divergence of human and chimpanzee lineages. The predicted amino acid sequences of mature ChLA-DRA and HLA-DRA molecules differ by only one amino acid.

Original languageEnglish (US)
Pages (from-to)107-121
Number of pages15
JournalHuman Immunology
Volume26
Issue number2
DOIs
StatePublished - Jan 1 1989

Fingerprint

Dichlororibofuranosylbenzimidazole
Pan troglodytes
Alleles
HLA-DR alpha-Chains
Genes
Prednisolone
Major Histocompatibility Complex
Gene Library
Amino Acid Sequence
Amino Acids

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Fan, W., Kasahara, M., Gutknecht, J., Klein, D., Mayer, W. E., Jonker, M., & Klein, J. (1989). Shared class II MHC polymorphisms between humans and chimpanzees. Human Immunology, 26(2), 107-121. https://doi.org/10.1016/0198-8859(89)90096-7
Fan, Weimin ; Kasahara, Masanori ; Gutknecht, Jutta ; Klein, Dagmar ; Mayer, Werner E. ; Jonker, Margreet ; Klein, Jan. / Shared class II MHC polymorphisms between humans and chimpanzees. In: Human Immunology. 1989 ; Vol. 26, No. 2. pp. 107-121.
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Fan, W, Kasahara, M, Gutknecht, J, Klein, D, Mayer, WE, Jonker, M & Klein, J 1989, 'Shared class II MHC polymorphisms between humans and chimpanzees', Human Immunology, vol. 26, no. 2, pp. 107-121. https://doi.org/10.1016/0198-8859(89)90096-7

Shared class II MHC polymorphisms between humans and chimpanzees. / Fan, Weimin; Kasahara, Masanori; Gutknecht, Jutta; Klein, Dagmar; Mayer, Werner E.; Jonker, Margreet; Klein, Jan.

In: Human Immunology, Vol. 26, No. 2, 01.01.1989, p. 107-121.

Research output: Contribution to journalArticle

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Fan W, Kasahara M, Gutknecht J, Klein D, Mayer WE, Jonker M et al. Shared class II MHC polymorphisms between humans and chimpanzees. Human Immunology. 1989 Jan 1;26(2):107-121. https://doi.org/10.1016/0198-8859(89)90096-7