Shear Field-Flow Fractionation: Theoretical Basis of a New, Highly Selective Technique

J. Calvin Giddings, Susan Louise Brantley

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Shear field-flow fractionation (shear FFF) is described as an FFF system in which shear forces are responsible for migration perpendicular to flow. It is shown that a desirable configuration for shear FFF is a concentric cylinder system with one cylinder rotating. After providing the relevant theoretical framework of FFF, the equations of Shafer et al. describing shear migration are simplified and applied to the limiting case of very thin annular spaces to get tractable retention expressions. On this basis the maximum selectivity is predicted to be 3 or greater, a value considerably higher than that for any other macromolecular separation technique. This high selectivity is confirmed using an alternate shear migration theory developed by Tirrell et al. However, it is shown that shear FFF is only applicable to macromolecules of high molecular weight, perhaps ~107 and above. It may also be applicable to globular particles.

Original languageEnglish (US)
Pages (from-to)631-651
Number of pages21
JournalSeparation Science and Technology
Volume19
Issue number10
DOIs
StatePublished - Aug 1 1984

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Fractionation
Flow fields
Macromolecules
Molecular weight

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Process Chemistry and Technology
  • Filtration and Separation

Cite this

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abstract = "Shear field-flow fractionation (shear FFF) is described as an FFF system in which shear forces are responsible for migration perpendicular to flow. It is shown that a desirable configuration for shear FFF is a concentric cylinder system with one cylinder rotating. After providing the relevant theoretical framework of FFF, the equations of Shafer et al. describing shear migration are simplified and applied to the limiting case of very thin annular spaces to get tractable retention expressions. On this basis the maximum selectivity is predicted to be 3 or greater, a value considerably higher than that for any other macromolecular separation technique. This high selectivity is confirmed using an alternate shear migration theory developed by Tirrell et al. However, it is shown that shear FFF is only applicable to macromolecules of high molecular weight, perhaps ~107 and above. It may also be applicable to globular particles.",
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Shear Field-Flow Fractionation : Theoretical Basis of a New, Highly Selective Technique. / Giddings, J. Calvin; Brantley, Susan Louise.

In: Separation Science and Technology, Vol. 19, No. 10, 01.08.1984, p. 631-651.

Research output: Contribution to journalArticle

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