Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders

Nicholas B. Gallo, Anirban Paul, Linda Van Aelst

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Chandelier cells (ChCs) are a unique type of GABAergic interneuron that selectively innervate the axon initial segment (AIS) of excitatory pyramidal neurons; the subcellular domain where action potentials are initiated. The proper genesis and maturation of ChCs is critical for regulating neural ensemble firing in the neocortex throughout development and adulthood. Recently, genetic and molecular studies have shed new light on the complex innerworkings of ChCs in health and disease. This review presents an overview of recent studies on the developmental origins, migratory properties, and morphology of ChCs. In addition, attention is given to newly identified molecules regulating ChC morphogenesis and connectivity as well as recent work linking ChC dysfunction to neural disorders, including schizophrenia, epilepsy, and autism spectrum disorder (ASD).

Original languageEnglish (US)
Pages (from-to)565-580
Number of pages16
JournalTrends in Neurosciences
Volume43
Issue number8
DOIs
StatePublished - Aug 2020

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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