Shedding light on the distinct functions of proteoglycans.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Heparan sulfate proteoglycans (HSPGs) are ubiquitous molecules that are critical for signaling mediated by many growth factors, including members of the Wnt, transforming growth factor-beta, Hedgehog, and fibroblast growth factor families, and are essential for cell specification, axon guidance, and the establishment of morphogen gradients. Although the heparan sulfate modifications of HSPGs are critical, there is much to learn about how the protein cores contribute to the specific signaling functions of these cell-surface and matrix molecules. Recent work has demonstrated that glypican-1 and syndecan-1 expressed by tumor cells have specific roles in FGF2 signaling, affecting their responses to this mitogenic stimulus.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Volume2006
Issue number329
DOIs
StatePublished - Jan 1 2006

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Proteoglycans
Heparan Sulfate Proteoglycans
Glypicans
Syndecan-1
Molecules
Heparitin Sulfate
Fibroblast Growth Factors
Fibroblast Growth Factor 2
Transforming Growth Factor beta
Tumors
Intercellular Signaling Peptides and Proteins
Cells
Specifications
Neoplasms
Proteins

Cite this

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Shedding light on the distinct functions of proteoglycans. / Selleck, Scott Brian.

In: Science's STKE : signal transduction knowledge environment, Vol. 2006, No. 329, 01.01.2006.

Research output: Contribution to journalArticle

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