Histological characterization is used in clinical and research contexts as a highly sensitive method for detecting the morphological features of disease and abnormal gene function. Histology has recently been accepted as a phenotyping method for the forthcoming Zebrafish Phenome Project, a large-scale community effort to characterize the morphological, physiological, and behavioral phenotypes resulting from the mutations in all known genes in the zebrafish genome. In support of this project, we present a novel content-based image retrieval system for the automated annotation of images containing histological abnormalities in the developing eye of the larval zebrafish.

Original languageEnglish (US)
Pages (from-to)401-440
Number of pages40
JournalMultimedia Tools and Applications
Issue number2
StatePublished - Jan 2011

All Science Journal Classification (ASJC) codes

  • Software
  • Media Technology
  • Hardware and Architecture
  • Computer Networks and Communications


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