SHIV susceptibility changes during the menstrual cycle of pigtail macaques

Ellen N. Kersh, Tara Henning, Sundaram A. Vishwanathan, Monica Morris, Katherine Butler, Debra R. Adams, Patricia Guenthner, Priya Srinivasan, James Smith, Jessica Ann Radzio-Basu, J. Gerardo Garcia-Lerma, Charles Dobard, Walid Heneine, Janet Mcnicholl

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: Hormonal changes during menstrual cycling may affect susceptibility to HIV. Methods: We determined the simian human immunodeficiency virus (SHIV) acquisition time point in 43 cycling pigtail macaques infected by repeated vaginal virus exposures initiated randomly in the cycle. Results: SHIV infection was first detected in the follicular phase in 38 macaques (88%), and in the luteal phase in five macaques (12%), indicating a statistically significant timing difference. Assuming a 7-day eclipse phase, most infections occurred during or following a high-progesterone period associated with menstruation, vaginal epithelium thinning, and suppressed mucosal immunity. Conclusions: This raises questions whether other high-progesterone conditions (pregnancy, hormonal contraception) similarly affect HIV risk.

Original languageEnglish (US)
Pages (from-to)310-316
Number of pages7
JournalJournal of Medical Primatology
Volume43
Issue number5
DOIs
StatePublished - Oct 1 2014

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Macaca nemestrina
Simian Immunodeficiency Virus
menstrual cycle
Human immunodeficiency virus
Menstrual Cycle
Macaca
HIV
progesterone
Progesterone
menstruation
mucosal immunity
contraception
HIV infections
corpus luteum
Mucosal Immunity
Follicular Phase
Menstruation
Luteal Phase
Virus Diseases
epithelium

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Kersh, E. N., Henning, T., Vishwanathan, S. A., Morris, M., Butler, K., Adams, D. R., ... Mcnicholl, J. (2014). SHIV susceptibility changes during the menstrual cycle of pigtail macaques. Journal of Medical Primatology, 43(5), 310-316. https://doi.org/10.1111/jmp.12124
Kersh, Ellen N. ; Henning, Tara ; Vishwanathan, Sundaram A. ; Morris, Monica ; Butler, Katherine ; Adams, Debra R. ; Guenthner, Patricia ; Srinivasan, Priya ; Smith, James ; Radzio-Basu, Jessica Ann ; Garcia-Lerma, J. Gerardo ; Dobard, Charles ; Heneine, Walid ; Mcnicholl, Janet. / SHIV susceptibility changes during the menstrual cycle of pigtail macaques. In: Journal of Medical Primatology. 2014 ; Vol. 43, No. 5. pp. 310-316.
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abstract = "Background: Hormonal changes during menstrual cycling may affect susceptibility to HIV. Methods: We determined the simian human immunodeficiency virus (SHIV) acquisition time point in 43 cycling pigtail macaques infected by repeated vaginal virus exposures initiated randomly in the cycle. Results: SHIV infection was first detected in the follicular phase in 38 macaques (88{\%}), and in the luteal phase in five macaques (12{\%}), indicating a statistically significant timing difference. Assuming a 7-day eclipse phase, most infections occurred during or following a high-progesterone period associated with menstruation, vaginal epithelium thinning, and suppressed mucosal immunity. Conclusions: This raises questions whether other high-progesterone conditions (pregnancy, hormonal contraception) similarly affect HIV risk.",
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Kersh, EN, Henning, T, Vishwanathan, SA, Morris, M, Butler, K, Adams, DR, Guenthner, P, Srinivasan, P, Smith, J, Radzio-Basu, JA, Garcia-Lerma, JG, Dobard, C, Heneine, W & Mcnicholl, J 2014, 'SHIV susceptibility changes during the menstrual cycle of pigtail macaques', Journal of Medical Primatology, vol. 43, no. 5, pp. 310-316. https://doi.org/10.1111/jmp.12124

SHIV susceptibility changes during the menstrual cycle of pigtail macaques. / Kersh, Ellen N.; Henning, Tara; Vishwanathan, Sundaram A.; Morris, Monica; Butler, Katherine; Adams, Debra R.; Guenthner, Patricia; Srinivasan, Priya; Smith, James; Radzio-Basu, Jessica Ann; Garcia-Lerma, J. Gerardo; Dobard, Charles; Heneine, Walid; Mcnicholl, Janet.

In: Journal of Medical Primatology, Vol. 43, No. 5, 01.10.2014, p. 310-316.

Research output: Contribution to journalArticle

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AU - Henning, Tara

AU - Vishwanathan, Sundaram A.

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AU - Butler, Katherine

AU - Adams, Debra R.

AU - Guenthner, Patricia

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AU - Smith, James

AU - Radzio-Basu, Jessica Ann

AU - Garcia-Lerma, J. Gerardo

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AU - Mcnicholl, Janet

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Kersh EN, Henning T, Vishwanathan SA, Morris M, Butler K, Adams DR et al. SHIV susceptibility changes during the menstrual cycle of pigtail macaques. Journal of Medical Primatology. 2014 Oct 1;43(5):310-316. https://doi.org/10.1111/jmp.12124