Short communication: Effects of 6-nitro substitution on 5-methylchrysene tumorigenicity, mutagenicity and metabolism

Karam El-Bayoumy, Shantu Amin, Stephen S. Hecht

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

6-Nitro-5-methylchrysene was prepared by nitration of 5-methylchrysene and the mutagenic and tumorigenic activities of the two compounds were compared. Whereas 5-methylchrysene was a strong tumor initiator on mouse skin, no tumors were observed in the mice treated with 6-nitro-5-methylchrysene. In Salmonella typhimurium TA100, both compounds were mutagenic in the presence, but not in the absence, of rat liver 9000 g supernatant. The major metabolite of 6-nitro-5-methylchrysene in rat liver in vitro was trans-1,2- dihydro-1,2- dihydroxy-6-nitro-5-methylchrysene. In view of the ready conversion of 6-nitro-5-methylchrysene to a 1,2-dihydrodiol, its apparent lack of tumorigenicity in mouse skin was intriguing.

Original languageEnglish (US)
Pages (from-to)673-676
Number of pages4
JournalCarcinogenesis
Volume7
Issue number4
DOIs
StatePublished - Dec 1 1986

All Science Journal Classification (ASJC) codes

  • Cancer Research

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