Short-term 17-β-estradiol administration does not affect metabolism in young males

M. A. Tarnopolsky, B. D. Roy, J. R. Macdonald, S. McKenzie, J. Martin, Steven Ettinger

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We have previously demonstrated that females oxidize more lipid and less protein and carbohydrate during endurance exercise [21]. Several studies in male rats have demonstrated similar metabolic changes after 4 d of 17-β-estradiol (E2) administration. Our purpose was to study the effects of E2 administration upon substrate metabolism during 90 min of cycle ergometry at 60% VO2peak in 11 healthy, young males. E2 was administered in a single-blind, cross-over, randomized fashion for 11 d (100μg·.1x3.5d→200μg·d.1 x3.5d→300μg· d.1x4.0 d). Respiratory exchange ratio (RER), VO2, Ve, HR, lactate, and glucose were measured every 30 min during exercise and E2, testosterone TEST, glycerol and triglycerides were measured prior to exercise T = 0 min. Muscle biopsies were taken from the vastus lateralis before and after exercise for glycogen determination. Estradiol treatment resulted in lower plasma TEST (20.8→7.8 nmol·L-1, P<0.0001) and higher plas E2 (168.1→327.3 pmol·L-1, P<0.002). There were no effects of E2 treatment upon any of the other measured variables including muscle glycogen: (E2-PRE=529.3→POST=237.9; PL-PRE=582.2→POST=262.4mmol·kg.1[dm]). We concluded that short-term E2 treatment increased plasma E2 to female follicular levels in males but had no effect upon lipid or carbohydrate metabolism.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalInternational Journal of Sports Medicine
Issue number3
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


Dive into the research topics of 'Short-term 17-β-estradiol administration does not affect metabolism in young males'. Together they form a unique fingerprint.

Cite this