@article{05c37f06ebd24482af2cd0872de1740a,
title = "Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction",
abstract = "Objective: To determine if short-term weight change among women with unexplained infertility (UI) and polycystic ovary syndrome (PCOS) undergoing ovulation induction is associated with live birth. Design: Secondary analysis of randomized trials. Setting: Multicenter fertility trial sites. Patient(s): A total of 900 women with UI and 750 women with PCOS. Main Outcome Measure(s): Live birth. Intervention(s): Weight assessment at enrollment and start of up to 4–5 cycles of clomiphene, letrozole, or gonadotropins and intrauterine insemination for women with UI and clomiphene or letrozole with regular intercourse for women with PCOS. Result(s): Weight data were available for 856 women with UI and 697 women with PCOS. Mean weight change was −0.2 ± 0.3 kg among women with UI and +2.2 ± 0.2 kg among women with PCOS and did not differ based on treatment allocation. There were 115 women with PCOS (16.4%) who gained ≥3 kg. Increased body mass index and three or more cycles were associated with weight gain in women with PCOS. There was no difference in live birth rate among women with PCOS and ≥3 kg weight gain and women with PCOS who did not gain weight. Conclusion(s): Women with PCOS gained an average of 2.2 kg regardless of the medication received, whereas women with UI experienced no short-term weight change during ovulation induction. Weight gain in women with PCOS was not associated with live birth rate.",
author = "{Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network} and Wendy Vitek and Fangbai Sun and Hoeger, {Kathleen M.} and Nanette Santoro and Diamond, {Michael P.} and Heping Zhang and Legro, {Richard S.} and C. Coutifaris and G. Christman and R. Robinson and R. Brzyski and W. Schlaff and P. Casson and Trussell, {J. C.} and E. Eisenberg and C. Lamar and L. DePaolo",
note = "Funding Information: Supported by grants from the (Clinical Research/Reproductive Scientist Training program (R25HD075737) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10 HD38992, U10HD055925, and U10 HD39005). W.V. has nothing to disclose. F.S. has nothing to disclose. K.M.H. has nothing to disclose and consultant for Bayer Pharmaceuticals, outside the submitted work. N.S. has nothing to disclose. M.P.D. is a member of the board of directors and a stockholder of Advanced Reproductive Care and report grants from NIH, during the conduct of the study. H.Z. consultant for Bayer Pharmaceuticals, outside the submitted work and report grants from NIH, during the conduct of the study. R.S.L. is a consultant for Bayer, Kindex, Odega, Millendo, and AbbVie, grants and consultant from Ferring outside the submitted work. Presented as an oral abstract at the American Society for Reproductive Medicine Scientific Congress and Expo, October 6–10, 2018, Denver, Colorado, where it received the Society for Reproductive Endocrinology and Infertility prize paper award: https://www.fertstert.org/article/S0015-0282(18)30799-4/fulltext. Funding Information: Supported by grants from the ( Clinical Research/Reproductive Scientist Training program ( R25HD075737 ) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( U10 HD38992 , U10HD055925 , and U10 HD39005 ). Publisher Copyright: {\textcopyright} 2020 American Society for Reproductive Medicine",
year = "2020",
month = nov,
doi = "10.1016/j.fertnstert.2020.06.002",
language = "English (US)",
volume = "114",
pages = "1032--1039",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "5",
}