Abstract
Sialidase in normal nononcogenic hamster embryo fibroblasts was not active toward added disialo- and trisialoganglioside, but all transformed lines of hamster embryo fibroblasts studied had sialidase active toward added ganglioside substrate. The levels of exogenous sialidase activity suggested a parallel trend in the amount of this activity and the degree of oncogenicity of the transformed cells. Exogenous sialidase activity in a weakly oncogenic cell line was found to increase after passage of the cells into hamsters and isolation and cell culture of the resulting tumors which gave rise to a cell line of relatively high oncogenicity.
Original language | English (US) |
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Pages (from-to) | 595-599 |
Number of pages | 5 |
Journal | Virology |
Volume | 58 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1974 |
All Science Journal Classification (ASJC) codes
- Virology