Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance

R. Bascom, J. Kesavanathan, T. K. Fitzgerald, K. H. Cheng, D. L. Swift

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min controlled exposure at rest to air or sidestream tobacco smoke (SS) (15 ppm CO) in a controlled environmental chamber. One hour after the exposure, 99mTc-sulfur colloid was aerosolized throughout the nasal passage and counts were measured with a scintillation detector. Six out of 12 subjects showed more rapid clearance after smoke exposure than after air exposure, and 3/12 had rapid clearance on both days. However, substantial decreases in clearance occurred in 3/12 subjects, all of whom had a history of ETS rhinitis. In two subjects, more than 90% of the tracer remained 1 hr after tracer administration (2 hr after smoke exposure). Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS.

Original languageEnglish (US)
Pages (from-to)1026-1030
Number of pages5
JournalEnvironmental health perspectives
Volume103
Issue number11
DOIs
StatePublished - Jan 1 1995

Fingerprint

Mucociliary Clearance
Nose
Smoke
Tobacco
Air
Colloids
Carbon Monoxide
Rhinitis
Sulfur
Biomarkers

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Bascom, R. ; Kesavanathan, J. ; Fitzgerald, T. K. ; Cheng, K. H. ; Swift, D. L. / Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance. In: Environmental health perspectives. 1995 ; Vol. 103, No. 11. pp. 1026-1030.
@article{aeec8ac3d5cb4c5d85d9e87fbd094ed8,
title = "Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance",
abstract = "Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min controlled exposure at rest to air or sidestream tobacco smoke (SS) (15 ppm CO) in a controlled environmental chamber. One hour after the exposure, 99mTc-sulfur colloid was aerosolized throughout the nasal passage and counts were measured with a scintillation detector. Six out of 12 subjects showed more rapid clearance after smoke exposure than after air exposure, and 3/12 had rapid clearance on both days. However, substantial decreases in clearance occurred in 3/12 subjects, all of whom had a history of ETS rhinitis. In two subjects, more than 90{\%} of the tracer remained 1 hr after tracer administration (2 hr after smoke exposure). Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS.",
author = "R. Bascom and J. Kesavanathan and Fitzgerald, {T. K.} and Cheng, {K. H.} and Swift, {D. L.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1289/ehp.951031026",
language = "English (US)",
volume = "103",
pages = "1026--1030",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "11",

}

Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance. / Bascom, R.; Kesavanathan, J.; Fitzgerald, T. K.; Cheng, K. H.; Swift, D. L.

In: Environmental health perspectives, Vol. 103, No. 11, 01.01.1995, p. 1026-1030.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance

AU - Bascom, R.

AU - Kesavanathan, J.

AU - Fitzgerald, T. K.

AU - Cheng, K. H.

AU - Swift, D. L.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min controlled exposure at rest to air or sidestream tobacco smoke (SS) (15 ppm CO) in a controlled environmental chamber. One hour after the exposure, 99mTc-sulfur colloid was aerosolized throughout the nasal passage and counts were measured with a scintillation detector. Six out of 12 subjects showed more rapid clearance after smoke exposure than after air exposure, and 3/12 had rapid clearance on both days. However, substantial decreases in clearance occurred in 3/12 subjects, all of whom had a history of ETS rhinitis. In two subjects, more than 90% of the tracer remained 1 hr after tracer administration (2 hr after smoke exposure). Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS.

AB - Nasal mucociliary clearance (NMC) is a biomarker of nasal mucosal function. Tobacco smokers have been shown to have abnormal NMC, but the acute effect of environmental tobacco smoke (ETS) on nonsmokers is unknown. This study evaluated acute tobacco smoke-induced alterations in NMC in 12 healthy adults. Subjects were studied on 2 days, separated by at least 1 week. Subjects underwent a 60-min controlled exposure at rest to air or sidestream tobacco smoke (SS) (15 ppm CO) in a controlled environmental chamber. One hour after the exposure, 99mTc-sulfur colloid was aerosolized throughout the nasal passage and counts were measured with a scintillation detector. Six out of 12 subjects showed more rapid clearance after smoke exposure than after air exposure, and 3/12 had rapid clearance on both days. However, substantial decreases in clearance occurred in 3/12 subjects, all of whom had a history of ETS rhinitis. In two subjects, more than 90% of the tracer remained 1 hr after tracer administration (2 hr after smoke exposure). Understanding the basis for biologic variability in the acute effect of tobacco smoke on NMC may advance our understanding of pathogenesis of chronic effects of ETS.

UR - http://www.scopus.com/inward/record.url?scp=0028839222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028839222&partnerID=8YFLogxK

U2 - 10.1289/ehp.951031026

DO - 10.1289/ehp.951031026

M3 - Article

C2 - 8605851

AN - SCOPUS:0028839222

VL - 103

SP - 1026

EP - 1030

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 11

ER -