Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine

Joshua C. Anthony, Tracy G. Anthony, Scot Kimball, Leonard "Jim" Jefferson

Research output: Contribution to journalArticle

266 Citations (Scopus)

Abstract

Numerous reports established that in skeletal muscle the indispensable branched-chain amino acid leucine is unique in its ability to initiate signal transduction pathways that modulate translation initiation. Oral administration of leucine stimulates protein synthesis in association with hyperphosphorylation of the translational repressor, eukaryotic initiation factor (elF) 4E binding protein 1 (4E-BP1), resulting in enhanced availability of the mRNA cap-binding protein elF4E, for binding elF4G and forming the active elF4F complex. In addition, leucine enhances phosphorylation of the 70-kDa ribosomal protein S6 kinase (S6K1). These results suggest that leucine upregulates protein synthesis in skeletal muscle by enhancing both the activity and synthesis of proteins involved in mRNA translation. The stimulatory effects of leucine on translation initiation are mediated in part through the protein kinase mammalian target of rapamycin (mTOR), where both insulin signaling and leucine signaling converge to promote a maximal response.

Original languageEnglish (US)
JournalJournal of Nutrition
Volume131
Issue number3
StatePublished - 2001

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Leucine
leucine
skeletal muscle
Skeletal Muscle
protein synthesis
translation (genetics)
Proteins
protein kinases
binding proteins
RNA Cap-Binding Proteins
Eukaryotic Initiation Factor-4E
70-kDa Ribosomal Protein S6 Kinases
Branched Chain Amino Acids
branched chain amino acids
ribosomal proteins
protein binding
Protein Biosynthesis
Sirolimus
Protein Binding
Protein Kinases

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

Anthony, Joshua C. ; Anthony, Tracy G. ; Kimball, Scot ; Jefferson, Leonard "Jim". / Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. In: Journal of Nutrition. 2001 ; Vol. 131, No. 3.
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Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. / Anthony, Joshua C.; Anthony, Tracy G.; Kimball, Scot; Jefferson, Leonard "Jim".

In: Journal of Nutrition, Vol. 131, No. 3, 2001.

Research output: Contribution to journalArticle

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