TY - JOUR
T1 - Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease
AU - O’connell, Timothy D.
AU - Murphy, Katherine A.
AU - Zhang, Naixin
AU - Puccini, Sara J.
AU - Healy, Chastity L.
AU - Harsch, Brian A.
AU - Zhang, Michael J.
AU - Shearer, Gregory C.
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH) Grants 1R01HL130099 (to T.D.O. and G.C.S.) and 1R01HL152215 (to T.D.O. and G.C.S.), Minnesota Obesity Prevention Training Program T32 NIH Grant 1T32DK083250-01A1 (to K.A.M.), and NIH Post-doctoral Fellowship F32HL152523 (to M.Z.).
Publisher Copyright:
© 2022 Int. Union Physiol. Sci./Am. Physiol. Soc.
PY - 2022/11
Y1 - 2022/11
N2 - A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.
AB - A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.
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U2 - 10.1152/physiol.00007.2022
DO - 10.1152/physiol.00007.2022
M3 - Review article
C2 - 35944007
AN - SCOPUS:85139571494
SN - 1548-9213
VL - 37
SP - 311
EP - 322
JO - Physiology
JF - Physiology
IS - 6
ER -