@article{3525e4aec0ae4f46a3033ff5677aede0,
title = "Signatures of mitonuclear coevolution in a warbler species complex",
abstract = "Divergent mitonuclear coadaptation could facilitate speciation. We investigate this possibility in two hybridizing species of warblers, Setophaga occidentalis and S. townsendi, in western North America. Inland S. townsendi harbor distinct mitochondrial DNA haplotypes from those of S. occidentalis. These populations also differ in several nuclear DNA regions. Coastal S. townsendi demonstrate mixed mitonuclear ancestry from S. occidentalis and inland S. townsendi. Of the few highly-differentiated chromosomal regions between inland S. townsendi and S. occidentalis, a 1.2 Mb gene block on chromosome 5 is also differentiated between coastal and inland S. townsendi. Genes in this block are associated with fatty acid oxidation and energy-related signaling transduction, thus linked to mitochondrial functions. Genetic variation within this candidate gene block covaries with mitochondrial DNA and shows signatures of divergent selection. Spatial variation in mitonuclear ancestries is correlated with climatic conditions. Together, these observations suggest divergent mitonuclear coadaptation underpins cryptic differentiation in this species complex.",
author = "Silu Wang and Ore, {Madelyn J.} and Mikkelsen, {Else K.} and Julie Lee-Yaw and Toews, {David P.L.} and Sievert Rohwer and Darren Irwin",
note = "Funding Information: In support of the Bird Names for Birds movement, we omitted the existing common name of Setophaga townsendi. We are grateful to Sharon Birks (Burke Museum) and Chris Wood (Burke Museum) for access to the tissue samples for sequencing. We thank Geoffrey E. Hill for inspiring ideas to this study. We also thank Gil Henriques for providing digital illustrations of the warblers. For helpful discussion we thank Sally Otto, Dolph Schluter, Loren Rieseberg, Graham Coop, Dahong Chen, Mike Whitlock, Andrea Thomaz, Armando Geraldes, Meade Krosby, Hernan Morales, Xinzhu Wei, Jared Grummer, Rohit Kolora, and Jessica Irwin. We are grateful for research funding provided by the Natural Sciences and Engineering Research Council of Canada (grants 311931-2012, RGPIN-2017-03919 and RGPAS-2017-507830 to DEI; and PGS D 331015731 to SW); Pennsylvania State University, the Eberly College of Science, and the Huck Institutes of the Life Sciences to DPLT; and a Werner and Hildegard Hesse Research Award in Ornithology and a UBC Four Year Doctoral Fellowship to SW. For research permits we thank Environment Canada; U. S. Geological Survey; Departments of Fish & Wildlife of Washington, Idaho, California, and Montana; and the UBC Animal Care Committee. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
day = "1",
doi = "10.1038/s41467-021-24586-8",
language = "English (US)",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}