Significance of pleural effusion in neuroblastoma

Himesh Gupta, John Conrad, Joseph D. Khoury, Lisa McGregor, Matthew J. Krasin, Jeffrey S. Dome, Victor M. Santana, Andrew M. Davidoff

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Pleural effusion is uncommon at diagnosis of neuroblastoma in children. Because the presence of malignant cells in pleural fluid may significantly change the management and outcome of patients with neuroblastoma, we retrospectively analyzed a cohort of neuroblastoma patients who presented with pleural effusion at the time of diagnosis to determine the incidence, presentation, stage, treatment, and outcome of these patients. Methods. We reviewed the presenting features of 295 patients with the diagnosis of neuroblastoma who received treatment at St. Jude Children's Research Hospital between 1991 and 2005. Patients were chosen for further analysis if pleural effusion had been identified on chest radiographs or computed tomography (CT) scans at diagnosis Results. Thirty-one out of 295(10.5%) patients with neuroblastoma had pleural effusion identified at time of presentation. International neuroblastoma staging system (INSS) risk stratification was high risk in 29 cases and intermediate risk and low risk in 1 case each. The primary site of disease was abdomen in 26 patients; mediastinum in 5. We conducted cytologic analysis of pleural fluid of nine patients; the specimen of seven contained malignant cells. Eighteen of 31 patients died of progressive or recurrent disease. Conclusion. In patients with neuroblastoma, pleural effusion is usually associated with unfavorable biologic features and high-risk disease. Pleural fluid should be examined cytologically and at a time when the results would change the risk stratification. There was no statistically significant difference in the survival rate of the patients with high-risk neuroblastoma with or without malignant pleural effusion.

Original languageEnglish (US)
Pages (from-to)906-908
Number of pages3
JournalPediatric Blood and Cancer
Volume49
Issue number7
DOIs
StatePublished - Dec 1 2007

Fingerprint

Pleural Effusion
Neuroblastoma
Malignant Pleural Effusion
Mediastinum
Abdomen
Thorax
Survival Rate
Tomography

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Gupta, H., Conrad, J., Khoury, J. D., McGregor, L., Krasin, M. J., Dome, J. S., ... Davidoff, A. M. (2007). Significance of pleural effusion in neuroblastoma. Pediatric Blood and Cancer, 49(7), 906-908. https://doi.org/10.1002/pbc.21199
Gupta, Himesh ; Conrad, John ; Khoury, Joseph D. ; McGregor, Lisa ; Krasin, Matthew J. ; Dome, Jeffrey S. ; Santana, Victor M. ; Davidoff, Andrew M. / Significance of pleural effusion in neuroblastoma. In: Pediatric Blood and Cancer. 2007 ; Vol. 49, No. 7. pp. 906-908.
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abstract = "Background. Pleural effusion is uncommon at diagnosis of neuroblastoma in children. Because the presence of malignant cells in pleural fluid may significantly change the management and outcome of patients with neuroblastoma, we retrospectively analyzed a cohort of neuroblastoma patients who presented with pleural effusion at the time of diagnosis to determine the incidence, presentation, stage, treatment, and outcome of these patients. Methods. We reviewed the presenting features of 295 patients with the diagnosis of neuroblastoma who received treatment at St. Jude Children's Research Hospital between 1991 and 2005. Patients were chosen for further analysis if pleural effusion had been identified on chest radiographs or computed tomography (CT) scans at diagnosis Results. Thirty-one out of 295(10.5{\%}) patients with neuroblastoma had pleural effusion identified at time of presentation. International neuroblastoma staging system (INSS) risk stratification was high risk in 29 cases and intermediate risk and low risk in 1 case each. The primary site of disease was abdomen in 26 patients; mediastinum in 5. We conducted cytologic analysis of pleural fluid of nine patients; the specimen of seven contained malignant cells. Eighteen of 31 patients died of progressive or recurrent disease. Conclusion. In patients with neuroblastoma, pleural effusion is usually associated with unfavorable biologic features and high-risk disease. Pleural fluid should be examined cytologically and at a time when the results would change the risk stratification. There was no statistically significant difference in the survival rate of the patients with high-risk neuroblastoma with or without malignant pleural effusion.",
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Gupta, H, Conrad, J, Khoury, JD, McGregor, L, Krasin, MJ, Dome, JS, Santana, VM & Davidoff, AM 2007, 'Significance of pleural effusion in neuroblastoma', Pediatric Blood and Cancer, vol. 49, no. 7, pp. 906-908. https://doi.org/10.1002/pbc.21199

Significance of pleural effusion in neuroblastoma. / Gupta, Himesh; Conrad, John; Khoury, Joseph D.; McGregor, Lisa; Krasin, Matthew J.; Dome, Jeffrey S.; Santana, Victor M.; Davidoff, Andrew M.

In: Pediatric Blood and Cancer, Vol. 49, No. 7, 01.12.2007, p. 906-908.

Research output: Contribution to journalArticle

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T1 - Significance of pleural effusion in neuroblastoma

AU - Gupta, Himesh

AU - Conrad, John

AU - Khoury, Joseph D.

AU - McGregor, Lisa

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N2 - Background. Pleural effusion is uncommon at diagnosis of neuroblastoma in children. Because the presence of malignant cells in pleural fluid may significantly change the management and outcome of patients with neuroblastoma, we retrospectively analyzed a cohort of neuroblastoma patients who presented with pleural effusion at the time of diagnosis to determine the incidence, presentation, stage, treatment, and outcome of these patients. Methods. We reviewed the presenting features of 295 patients with the diagnosis of neuroblastoma who received treatment at St. Jude Children's Research Hospital between 1991 and 2005. Patients were chosen for further analysis if pleural effusion had been identified on chest radiographs or computed tomography (CT) scans at diagnosis Results. Thirty-one out of 295(10.5%) patients with neuroblastoma had pleural effusion identified at time of presentation. International neuroblastoma staging system (INSS) risk stratification was high risk in 29 cases and intermediate risk and low risk in 1 case each. The primary site of disease was abdomen in 26 patients; mediastinum in 5. We conducted cytologic analysis of pleural fluid of nine patients; the specimen of seven contained malignant cells. Eighteen of 31 patients died of progressive or recurrent disease. Conclusion. In patients with neuroblastoma, pleural effusion is usually associated with unfavorable biologic features and high-risk disease. Pleural fluid should be examined cytologically and at a time when the results would change the risk stratification. There was no statistically significant difference in the survival rate of the patients with high-risk neuroblastoma with or without malignant pleural effusion.

AB - Background. Pleural effusion is uncommon at diagnosis of neuroblastoma in children. Because the presence of malignant cells in pleural fluid may significantly change the management and outcome of patients with neuroblastoma, we retrospectively analyzed a cohort of neuroblastoma patients who presented with pleural effusion at the time of diagnosis to determine the incidence, presentation, stage, treatment, and outcome of these patients. Methods. We reviewed the presenting features of 295 patients with the diagnosis of neuroblastoma who received treatment at St. Jude Children's Research Hospital between 1991 and 2005. Patients were chosen for further analysis if pleural effusion had been identified on chest radiographs or computed tomography (CT) scans at diagnosis Results. Thirty-one out of 295(10.5%) patients with neuroblastoma had pleural effusion identified at time of presentation. International neuroblastoma staging system (INSS) risk stratification was high risk in 29 cases and intermediate risk and low risk in 1 case each. The primary site of disease was abdomen in 26 patients; mediastinum in 5. We conducted cytologic analysis of pleural fluid of nine patients; the specimen of seven contained malignant cells. Eighteen of 31 patients died of progressive or recurrent disease. Conclusion. In patients with neuroblastoma, pleural effusion is usually associated with unfavorable biologic features and high-risk disease. Pleural fluid should be examined cytologically and at a time when the results would change the risk stratification. There was no statistically significant difference in the survival rate of the patients with high-risk neuroblastoma with or without malignant pleural effusion.

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Gupta H, Conrad J, Khoury JD, McGregor L, Krasin MJ, Dome JS et al. Significance of pleural effusion in neuroblastoma. Pediatric Blood and Cancer. 2007 Dec 1;49(7):906-908. https://doi.org/10.1002/pbc.21199