Abstract
We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1(HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.
Original language | English (US) |
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Pages (from-to) | 1924-1926 |
Number of pages | 3 |
Journal | Blood |
Volume | 76 |
Issue number | 10 |
DOIs | |
State | Published - 1990 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Immunology
- Hematology
- Cell Biology