Abstract
We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1(HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1924-1926 |
| Number of pages | 3 |
| Journal | Blood |
| Volume | 76 |
| Issue number | 10 |
| State | Published - Jan 1 1990 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Immunology
- Hematology
- Cell Biology
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Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs. / Gibbons, J.; Cory, J. M.; Hewlett, I. K.; Epstein, J. S.; Eyster, M. E.
In: Blood, Vol. 76, No. 10, 01.01.1990, p. 1924-1926.Research output: Contribution to journal › Article
TY - JOUR
T1 - Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs
AU - Gibbons, J.
AU - Cory, J. M.
AU - Hewlett, I. K.
AU - Epstein, J. S.
AU - Eyster, M. E.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1(HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.
AB - We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1(HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025226502&partnerID=8YFLogxK
M3 - Article
C2 - 2242420
AN - SCOPUS:0025226502
VL - 76
SP - 1924
EP - 1926
JO - Blood
JF - Blood
SN - 0006-4971
IS - 10
ER -