Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs

J. Gibbons, J. M. Cory, I. K. Hewlett, J. S. Epstein, M. E. Eyster

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1(HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.

    Original languageEnglish (US)
    Pages (from-to)1924-1926
    Number of pages3
    JournalBlood
    Volume76
    Issue number10
    StatePublished - Jan 1 1990

    Fingerprint

    Hemophilia A
    Viruses
    HIV-1
    Polymerase chain reaction
    Infection
    Blood
    Sexual Partners
    Virus Diseases
    HIV Infections
    Antibodies
    DNA
    Cross-Sectional Studies
    Polymerase Chain Reaction

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology

    Cite this

    Gibbons, J. ; Cory, J. M. ; Hewlett, I. K. ; Epstein, J. S. ; Eyster, M. E. / Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs. In: Blood. 1990 ; Vol. 76, No. 10. pp. 1924-1926.
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    Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs. / Gibbons, J.; Cory, J. M.; Hewlett, I. K.; Epstein, J. S.; Eyster, M. E.

    In: Blood, Vol. 76, No. 10, 01.01.1990, p. 1924-1926.

    Research output: Contribution to journalArticle

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