Silent infections with human immunodeficiency virus type 1 are highly unlikely in multitransfused seronegative hemophiliacs

J. Gibbons, J. M. Cory, I. K. Hewlett, J. S. Epstein, M. E. Eyster

    Research output: Contribution to journalArticlepeer-review

    19 Scopus citations

    Abstract

    We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1(HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.

    Original languageEnglish (US)
    Pages (from-to)1924-1926
    Number of pages3
    JournalBlood
    Volume76
    Issue number10
    DOIs
    StatePublished - 1990

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology

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