We used the polymerase chain reaction (PCR) to determine the frequency of silent human immunodeficiency virus type 1(HIV-1) infections in seronegative high-risk individuals with hemophilia who had been exposed to contaminated blood products more than 3 years previously. In a cross-sectional study of a cohort of 57 prospectively followed seronegative hemophiliacs who received multiple transfusions before 1986, HIV-1 proviral DNA was found transiently in only one patient. These data suggest that the rate of HIV infection among high-risk antibody negative individuals with hemophilia is very low to absent, in the range of 0% to 2%. These findings should provide considerable reassurance to seronegative persons with hemophilia and their sexual partners.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 1990|
All Science Journal Classification (ASJC) codes
- Cell Biology