Silicon nanopore membrane technology for an implantable artificial kidney

Shuvo Roy, Anna Dubnisheva, Abigail Eldridge, Aaron J. Fleischman, Kenneth G. Goldman, H. David Humes, Andrew Zydney, William H. Fissell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

High performance silicon nanoporous membranes have been developed to investigate the feasibility of an implantable bioartificial kidney. The nanoscale pore size is defined by the thickness of a sacrificial layer of silicon dioxide (SiO2), which is grown by thermal oxidation down to 5 nm with 1% variation. Standardized test protocols to examine biocompatibility revealed that silicon and related MEMS materials did not exhibit any evidence of cytotoxicity or hemolysis. Surface modification with polyethylene glycol (PEG) monolayers reduced adsorption of bovine serum albumin (BSA) onto MEMS surfaces to ∼4% of positive control. PEG-modified membranes exhibited size-dependent rejection of Ficoll 70, a spherical probe solute, dissolved in bovine whole blood. Prolonged hemofiltration revealed constant membrane flux and consistent molecular selectivity for >72 hours.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages755-760
Number of pages6
DOIs
StatePublished - Dec 11 2009
EventTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States
Duration: Jun 21 2009Jun 25 2009

Publication series

NameTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

OtherTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
CountryUnited States
CityDenver, CO
Period6/21/096/25/09

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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    Roy, S., Dubnisheva, A., Eldridge, A., Fleischman, A. J., Goldman, K. G., Humes, H. D., Zydney, A., & Fissell, W. H. (2009). Silicon nanopore membrane technology for an implantable artificial kidney. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 755-760). [5285603] (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285603