Silicon oxycarbide glasses for blood-contact applications

Rui Zhuo, Paolo Colombo, Carlo Pantano, Erwin A. Vogler

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Silicon oxycarbide (SiOxCy) glass compositions are shown to exhibit a variable propensity to contact activate coagulation of whole human blood plasma that depends on X:Y surface stoichiometry. SiOxCy exhibit activation properties similar to pyrolytic carbon (PC) over a broad range of X:Y ratios. Surface composition of SiOxCy glass powders prepared by pyrolysis of thermosetting polysilsequioxanes roughly correlated with total carbon concentration of precursor resins and could be significantly modified by etching in alkaline solutions. Results suggest that SiOxCy may offer unique properties as a substitute for PC in medical-device applications demanding excellent tribological properties, such as artificial heart valves.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalActa Biomaterialia
Issue number5
StatePublished - Sep 2005

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology


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