Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling

Kelly A. Ryan, Shervin Assari, Bethany D. Pester, Kristin Hinrichs, Kaley Angers, Amanda Baker, David F. Marshall, Deborah Stringer, Erika F. H. Saunders, Masoud Kamali, Melvin G. McInnis, Scott A. Langenecker

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective Executive Functioning (EF) deficits in bipolar disorder (BD) are commonly present regardless of mood state and therefore are considered core features of the illness. However, very little is known about the temporal stability of these deficits. We examined the natural course of EF over a five year period in BD and healthy control (HC) samples. Method Using a 5-year longitudinal cohort, 91 individuals with BD and 17 HC were administered a battery of neuropsychological tests that captured four main areas of EF: Processing Speed with Interference Resolution, Verbal Fluency with Processing Speed, Inhibitory Control, and Conceptual Reasoning and Set Shifting. Evaluations occurred at study entry, one, and five years later. Results Latent Growth Curve Modeling demonstrated that the BD group performed significantly worse in all EF areas than the HC group. Changes in EF from baseline to 5-year follow-up were similar across both diagnostic groups. Older age at baseline, above and beyond education and diagnosis, was associated with worse initial performance in EF. Being of older age was associated with greater decline in Processing Speed with Interference Resolution, and Verbal Fluency with Processing Speed. Higher education was marginally associated with a smaller declining slope for Processing Speed with Interference Resolution. Conclusions Executive functioning deficits in BD persist over time, and in the context of normative age-related decline, may place individuals at greater risk for cognitive disability as the disease progresses. Age and having a BD diagnosis together, however, do not accelerate executive functioning decline over time.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalJournal of Affective Disorders
Volume199
DOIs
StatePublished - Jul 15 2016

Fingerprint

Bipolar Disorder
Growth
Education
Neuropsychological Tests
Control Groups

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Ryan, Kelly A. ; Assari, Shervin ; Pester, Bethany D. ; Hinrichs, Kristin ; Angers, Kaley ; Baker, Amanda ; Marshall, David F. ; Stringer, Deborah ; Saunders, Erika F. H. ; Kamali, Masoud ; McInnis, Melvin G. ; Langenecker, Scott A. / Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling. In: Journal of Affective Disorders. 2016 ; Vol. 199. pp. 87-94.
@article{2b9e0b27b7be4e4da6d448b5c5d36357,
title = "Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling",
abstract = "Objective Executive Functioning (EF) deficits in bipolar disorder (BD) are commonly present regardless of mood state and therefore are considered core features of the illness. However, very little is known about the temporal stability of these deficits. We examined the natural course of EF over a five year period in BD and healthy control (HC) samples. Method Using a 5-year longitudinal cohort, 91 individuals with BD and 17 HC were administered a battery of neuropsychological tests that captured four main areas of EF: Processing Speed with Interference Resolution, Verbal Fluency with Processing Speed, Inhibitory Control, and Conceptual Reasoning and Set Shifting. Evaluations occurred at study entry, one, and five years later. Results Latent Growth Curve Modeling demonstrated that the BD group performed significantly worse in all EF areas than the HC group. Changes in EF from baseline to 5-year follow-up were similar across both diagnostic groups. Older age at baseline, above and beyond education and diagnosis, was associated with worse initial performance in EF. Being of older age was associated with greater decline in Processing Speed with Interference Resolution, and Verbal Fluency with Processing Speed. Higher education was marginally associated with a smaller declining slope for Processing Speed with Interference Resolution. Conclusions Executive functioning deficits in BD persist over time, and in the context of normative age-related decline, may place individuals at greater risk for cognitive disability as the disease progresses. Age and having a BD diagnosis together, however, do not accelerate executive functioning decline over time.",
author = "Ryan, {Kelly A.} and Shervin Assari and Pester, {Bethany D.} and Kristin Hinrichs and Kaley Angers and Amanda Baker and Marshall, {David F.} and Deborah Stringer and Saunders, {Erika F. H.} and Masoud Kamali and McInnis, {Melvin G.} and Langenecker, {Scott A.}",
year = "2016",
month = "7",
day = "15",
doi = "10.1016/j.jad.2016.04.016",
language = "English (US)",
volume = "199",
pages = "87--94",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

Ryan, KA, Assari, S, Pester, BD, Hinrichs, K, Angers, K, Baker, A, Marshall, DF, Stringer, D, Saunders, EFH, Kamali, M, McInnis, MG & Langenecker, SA 2016, 'Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling', Journal of Affective Disorders, vol. 199, pp. 87-94. https://doi.org/10.1016/j.jad.2016.04.016

Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling. / Ryan, Kelly A.; Assari, Shervin; Pester, Bethany D.; Hinrichs, Kristin; Angers, Kaley; Baker, Amanda; Marshall, David F.; Stringer, Deborah; Saunders, Erika F. H.; Kamali, Masoud; McInnis, Melvin G.; Langenecker, Scott A.

In: Journal of Affective Disorders, Vol. 199, 15.07.2016, p. 87-94.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Similar Trajectory of Executive Functioning Performance over 5 years among individuals with Bipolar Disorder and Unaffected Controls using Latent Growth Modeling

AU - Ryan, Kelly A.

AU - Assari, Shervin

AU - Pester, Bethany D.

AU - Hinrichs, Kristin

AU - Angers, Kaley

AU - Baker, Amanda

AU - Marshall, David F.

AU - Stringer, Deborah

AU - Saunders, Erika F. H.

AU - Kamali, Masoud

AU - McInnis, Melvin G.

AU - Langenecker, Scott A.

PY - 2016/7/15

Y1 - 2016/7/15

N2 - Objective Executive Functioning (EF) deficits in bipolar disorder (BD) are commonly present regardless of mood state and therefore are considered core features of the illness. However, very little is known about the temporal stability of these deficits. We examined the natural course of EF over a five year period in BD and healthy control (HC) samples. Method Using a 5-year longitudinal cohort, 91 individuals with BD and 17 HC were administered a battery of neuropsychological tests that captured four main areas of EF: Processing Speed with Interference Resolution, Verbal Fluency with Processing Speed, Inhibitory Control, and Conceptual Reasoning and Set Shifting. Evaluations occurred at study entry, one, and five years later. Results Latent Growth Curve Modeling demonstrated that the BD group performed significantly worse in all EF areas than the HC group. Changes in EF from baseline to 5-year follow-up were similar across both diagnostic groups. Older age at baseline, above and beyond education and diagnosis, was associated with worse initial performance in EF. Being of older age was associated with greater decline in Processing Speed with Interference Resolution, and Verbal Fluency with Processing Speed. Higher education was marginally associated with a smaller declining slope for Processing Speed with Interference Resolution. Conclusions Executive functioning deficits in BD persist over time, and in the context of normative age-related decline, may place individuals at greater risk for cognitive disability as the disease progresses. Age and having a BD diagnosis together, however, do not accelerate executive functioning decline over time.

AB - Objective Executive Functioning (EF) deficits in bipolar disorder (BD) are commonly present regardless of mood state and therefore are considered core features of the illness. However, very little is known about the temporal stability of these deficits. We examined the natural course of EF over a five year period in BD and healthy control (HC) samples. Method Using a 5-year longitudinal cohort, 91 individuals with BD and 17 HC were administered a battery of neuropsychological tests that captured four main areas of EF: Processing Speed with Interference Resolution, Verbal Fluency with Processing Speed, Inhibitory Control, and Conceptual Reasoning and Set Shifting. Evaluations occurred at study entry, one, and five years later. Results Latent Growth Curve Modeling demonstrated that the BD group performed significantly worse in all EF areas than the HC group. Changes in EF from baseline to 5-year follow-up were similar across both diagnostic groups. Older age at baseline, above and beyond education and diagnosis, was associated with worse initial performance in EF. Being of older age was associated with greater decline in Processing Speed with Interference Resolution, and Verbal Fluency with Processing Speed. Higher education was marginally associated with a smaller declining slope for Processing Speed with Interference Resolution. Conclusions Executive functioning deficits in BD persist over time, and in the context of normative age-related decline, may place individuals at greater risk for cognitive disability as the disease progresses. Age and having a BD diagnosis together, however, do not accelerate executive functioning decline over time.

UR - http://www.scopus.com/inward/record.url?scp=84963831974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963831974&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2016.04.016

DO - 10.1016/j.jad.2016.04.016

M3 - Article

VL - 199

SP - 87

EP - 94

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -