Oilfield problems owing to asphaitene precipitation are well known. Asphaltenes can block pore throats or change the formation wettability and thereby reduce the hydrocarbon mobility. Simulation of asphaitene precipitation during gas injection requires a comprehensive thermodynamic model, which accounts for the complex phase behavior of asphaltenes. In this paper, PC-SAFT EOS is implemented for the first time in a compositional reservoir simulator to model asphaitene precipitation. The additional computational time of PC-SAFT compared to the cubic equations-of-state such as Pen-Robinson (PR EOS) is decreased by improving its root finding algorithm. A deposition and wettability alteration model is then integrated with the thermodynamic model to simulate the dynamics of precipitated asphaltenes. Different gas injection scenarios are modeled to show the effect of gas injection on apshaltene precipitation and deposition. Simulation results show that the profile of the damaged area by asphaitene deposition is governed by the shape of the asphaitene precipitation envelope for the reservoir fluid. The damage caused by asphaitene deposition, through plugging and wettability alteration, was revealed as a decline in productivity index curves. Results indicate that a reservoir fluid can have precipitation risk during gas injection even if it does not exhibit precipitation in the primary recovery life of a field. The computational time of the simulations using PC-SAFT EOS were compared to those using PR EOS for different number of components. Results of these comparisons show the feasibility of using PC-SAFT in compositional simulations.