Simultaneous genetic analysis of longitudinal means and covariance structure in the simplex model using twin data

Conor V. Dolan, Peter C.M. Molenaar, Dorret I. Boomsma

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A longitudinal model based on the simplex model is presented to analyze simultaneously means and covariance structure using univariate longitudinal twin data. The objective of the model is to decompose the mean trend into components which can be attributed to those genetic and environmental factors which give rise to phenotypic individual differences and a component of unknown constitution which does not involve individual differences. Illustrations are given using simulated data and repeatedly measured weight obtained in a sample of 82 female twin pairs on six occasions.

Original languageEnglish (US)
Pages (from-to)49-65
Number of pages17
JournalBehavior Genetics
Volume21
Issue number1
DOIs
StatePublished - Jan 1991

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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